C11100P

DMT-dC(bz) Pharmadite^®

• Sinonimo/i: DMT-dC(bz) Phosphoramidite, N-benzoyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxycytidine, 3′-[2-cyanoethyl N,N-?bis(1-methylethyl)phosphoramidite]
• Formula empirica (notazione di Hill): C₄₆H₅₂N₅O₈P
• Peso molecolare: 833.91
• Numero MDL: MFCD00036315
• Codice UNSPSC: 12352200
• ID PubChem: 329774847
• NACRES: NA.51

Proprietà

• Origine biologica: non-animal source (no BSE/TSE risk)
• Livello qualitativo: 300
• Tipo: for DNA synthesis
• Nome Commerciale: Proligo Reagents
• Saggio: ≥99.5% (reversed phase HPLC); >99.5% (³¹P-NMR)
• Forma fisica: powder or granules
• tecniche: oligo synthesis: suitable
• Impurezze: >= 170ppm, none detected (S/N <2.5); ≤0.1% P(III) 100-169ppm (³¹P-NMR); ≤0.1% single unspecified Imprity (reversed phase HPLC); ≤0.3% dC2 (reversed phase HPLC, DMT-dC(bz) cyanoethyl-H-posphonate); ≤0.3% dC3 (reversed phase HPLC, DMT-dC(bz) phosphoramidate); ≤0.3% dC5 (reversed phase HPLC, O3′-Benzoyl-O5′-DMT-dC(bz)); ≤0.30 wt. % water content (Karl Fischer); ≤0.5% P(V) -25-99ppm (³¹P-NMR); ≤3.0 wt. % residual solvent content
• Colore: white to off-white
• Solubilità: soluble, clear
• Compatibilità: conforms to structure for H-NMR; conforms to structure for LC-MS
• Profilo del nucleoside: base: deoxycytidine; base protecting group: benzoyl; 2' protecting group: none; 5' protecting group: DMT; deprotection: standard
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: COc1ccc(cc1)C(OC[C@H]2O[C@H](C[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)N3C=CC(NC(=O)c4ccccc4)=NC3=O)(c5ccccc5)c6ccc(OC)cc6
• InChI: 1S/C46H52N5O8P/c1-32(2)51(33(3)4)60(57-29-13-27-47)59-40-30-43(50-28-26-42(49-45(50)53)48-44(52)34-14-9-7-10-15-34)58-41(40)31-56-46(35-16-11-8-12-17-35,36-18-22-38(54-5)23-19-36)37-20-24-39(55-6)25-21-37/h7-12,14-26,28,32-33,40-41,43H,13,29-31H2,1-6H3,(H,48,49,52,53)/t40-,41+,43+,60?/m0/s1; PGTNFMKLGRFZDX-SALLYJDFSA-N

Descrizione

Descrizione generale

DMT-dC(bz) Pharmadite^® is a Pharmadite^® product line that represents a new class of standard protected DNA phosphoramidites designed with highly controlled impurity profiles and exceptional overall purity.Pharmadite phosphoramidites are characterized by their exceptional purity and well-defined impurity profile. In particular, they are essentially free fromcontaminants that interfere in coupling reactions, such as other nucleosidic or non-nucleosidic phosphoramidites (P(III)-contaminants). All remainingimpurities in Pharmadite phosphopramidites, if present, are identified, characterized, and quantified. The impact of any such defined impurities on the synthesis of oligonucleotides is well understood and has been shown to be insignificant.

Note legali

Pharmadite is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable