AC-0352A

Claudin-4 (EP417) Rabbit Monoclonal Primary Antibody

• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Forma dell’anticorpo: Ig fraction of antiserum
• Clone: monoclonal
• Descrizione: For In Vitro Diagnostic Use in Select Regions (See Chart)
• Forma fisica: buffered aqueous solution
• tecniche: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:200
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: 2-8°C
• Visualizzazione: (membrane)

Descrizione

Descrizione generale

Claudin-4 is one of twenty-seven integral membrane tight junction proteins and specializes in paracellular sodium transport. Although claudin proteins are primarily known for their cell adhesion function, Claudin-4 binds to zonula occludens proteins and interacts with numerous signaling pathways. Claudin-4 is detectable in low amounts in the normal tissues of the lung, kidney, breast, prostate, bladder and gastrointestinal tract. It is a highly specific and sensitive membranous marker for most epithelial neoplasms. Absence of expression in normal mesothelium and mesothelioma provides utility in the differential diagnosis between carcinoma from mesothelioma with 99% specificity. In breast tumors, claudin-4 levels are significantly higher in ER-negative and high grade tumors when compared to ER-positive and low grade tumors. High levels of Claudin-4 expression are associated with later stages of progression and reduced patient survival for most types of epithelial neoplasms. Conversely, its expression is downregulated in gastric and high-grade bladder cancers, and is significantly lower in lymph node metastasis and esophageal tumors with distant metastasis. Low Claudin-4 expression is associated with a poor prognosis in esophageal squamous cell carcinoma.

Qualità

IVD

IVD

IVD

RUO

Stato fisico

Solution in Tris Buffer, pH 7.3-7.7, with 1%BSA and &< 0.1% Sodium Azide

Altre note

For a copy of the IFU and CofA contact IVDorder@ABCAM.com

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable