AC-0341A

HSP70 (EP377) Rabbit Monoclonal Primary Antibody

• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Forma dell’anticorpo: Ig fraction of antiserum
• Clone: monoclonal
• Descrizione: For In Vitro Diagnostic Use in Select Regions (See Chart)
• Forma fisica: buffered aqueous solution
• tecniche: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:200
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: 2-8°C
• Visualizzazione: nuclear

Descrizione

Descrizione generale

The heat shock proteins (HSPs) are a conserved family of ubiquitously expressed proteins that functions to protect cells from various environmental damage. Two proteins within the family, HSP70 and HSP27 demonstrate strong anti-apoptotic activity; its overexpression allow cells to survive in variable conditions. HSPs have been implicated in tumorigenesis – affecting cell cycle regulation, multidrug resistance and modulating p53 function. HSP70 has been studied in a variety of malignancies, including breast, lung, oral, prostate and uterine-cervical cancers. A majority of results associated HSP70 overexpression with poor prognosis and resistance to therapy. Recently, HSP70 diagnostic utility was established in identifying hepatocellular carcinoma (HCC). HSP70 was the most abundantly up-regulated gene in advanced HCC and its immunoreactivity was seen in the majority of HCC. Its sensitivity and specificity were determined as 74% and 98%, respectively. Furthermore, a three antibody panel with HSP70, Glypican 3, and Glutamine Synthetase is capable of distinguishing HCC from high grade dysplastic nodules with 100% specificity when 2 markers are positive.

Qualità

IVD

IVD

IVD

RUO

Stato fisico

Solution in Tris Buffer, pH 7.3-7.7, with 1%BSA and &< 0.1% Sodium Azide

Altre note

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Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable