A8126

Acriflavine

Powder

• Sinonimo/i: 3,6-Diamino-10-methylacridinium chloride mixt. with 3,6-diaminoacridine (proflavine), Euflavine, Trypaflavine Neutral
• Formula empirica (notazione di Hill): C₁₄H₁₄ClN₃
• Numero CAS: 8048-52-0
• Peso molecolare: 259.73
• Numero MDL: MFCD00064307
• Codice UNSPSC: 12171500
• ID PubChem: 24891319
• NACRES: NA.47

Proprietà

• product name: Acriflavine, fluorescent label
• Livello qualitativo: 200
• Forma fisica: powder
• Punto di fusione: 179-181 °C
• Solubilità: H₂O: 0.33 g/mL (lit.)(lit.)
• εmax: ≥48000 at 459-465 nm in methanol at 0.004 g/L; ≥50000 at 259-265 nm in methanol at 0.004 g/L
• applicazioni: diagnostic assay manufacturing; hematology; histology
• Temperatura di conservazione: room temp
• Stringa SMILE: [Cl-].Nc1ccc2cc3ccc(N)cc3nc2c1.C[n+]4c5cc(N)ccc5cc6ccc(N)cc46
• InChI: 1S/C14H13N3.C13H11N3.ClH/c1-17-13-7-11(15)4-2-9(13)6-10-3-5-12(16)8-14(10)17;14-10-3-1-8-5-9-2-4-11(15)7-13(9)16-12(8)6-10;/h2-8H,1H3,(H3,15,16);1-7H,14-15H2;1H; PEJLNXHANOHNSU-UHFFFAOYSA-N

Descrizione

Applicazioni

Acriflavine is used to fluorescently label high molecular weight RNA molecules .
Excitation and emission wavelengths in various solvents :

• Methanol: λex = 424 nm; λem = 518 nm
• Ethanol: λex = 426 nm; λem = 524 nm
• Propanol: λex = 430 nm; λem = 512 nm
• Butanol: λex = 430 nm; λem = 526 nm
• Formamide: λex = 434 nm; λem = 524 nm
• Glycerol: λex = 432 nm; λem = 540 nm
• Water: λex = 416 nm; λem = 514 nm

Insoluble in ether, chloroform, and fixed oils. Utilized in fluorescence steady state measurements as a donor molecule (when paired with rhodamine 6G as the acceptor) to function as a pH sensor .

• Acriflavine has been used in the agglutination test to distinguish between smooth and rough colony formation of Brucella melitensis.
• It has been used as an Ago2 (argonaute 2) inhibitor.
• It has been used as an inhibitor of HIF-ARNT (hypoxia-inducible factor - aryl hydrocarbon receptor nuclear translocator) complex formation.
• It has been used to study the bacteriocin production by Carnobacterium piscicola.

Azioni biochim/fisiol

Acriflavine also interacts with HIF-1α (hypoxia-inducible factor 1 α) and HIF-2α, and thereby suppresses dimer formation of HIF-1 and transcriptional function. It also has negative effect on tumor growth and vascularization. Acriflavine also exhibits trypanocidal, antibacterial and antiviral activities.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302,H315,H319,H335
• Consigli di prudenza: P261 - P264 - P271 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Classi di pericolo: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organi bersaglio: Respiratory system
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable