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A6218

Sigma-Aldrich

Anti-ATM antibody, Mouse monoclonal

clone SYML6A10, purified from hybridoma cell culture

Sinonimo/i:

Monoclonal Anti-ATM antibody produced in mouse, Anti-Ataxia-Telangiectasia Mutated

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About This Item

Numero MDL:
MFCD01321740
Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

mouse

Coniugato

unconjugated

Forma dell’anticorpo

purified immunoglobulin

Tipo di anticorpo

primary antibodies

Clone

SYML6A10, monoclonal

Stato

buffered aqueous solution

PM

antigen ~350 kDa

Reattività contro le specie

human

tecniche

immunocytochemistry: suitable
microarray: suitable
western blot: 1-2 μg/mL using total cell extract from a G-361 (human melanoma) cell line

Isotipo

IgG1

N° accesso UniProt

Q13315

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... ATM(472)

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Descrizione generale

Ataxia-Telangiectasia Mutated (ATM) is a member of the phosphatidylinositol 3-kinase (PI-3) family of kinases. It is activated in response to DNA damage such as double stranded breaks.
Mouse Monoclonal Anti-ATM antibody binds to human ATM.

Immunogeno

synthetic peptide corresponding to the C-terminal region of human ATM with N-terminally added cysteine, conjugated to KLH.

Applicazioni

Mouse Monoclonal Anti-ATM antibody can be used for western blot assays at 1-2μg/ml using G-361 cell extracts. The antibody can also be used for immunocytochemistry and microarray applications.

Stato fisico

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Certificati d'analisi (COA)

Lot/Batch Number
116M4777
013K4874

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Carcinogenesis, 24(10), 1571-1580 (2003-08-16)
Exposure to genotoxic agents is a major cause of human cancer, and cellular responses to genotoxic stress are important defense mechanisms. These responses are very complex, involving many cellular factors that form an extensive signal transduction network. This network includes
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Cancer research, 72(9), 2206-2217 (2012-03-06)
RASSF1A (Ras association domain containing family 1A), a tumor suppressor gene that is frequently inactivated in human cancers, is phosphorylated by ataxia telangiectasia mutated (ATM) on Ser131 upon DNA damage, leading to activation of a p73-dependent apoptotic response. A single-nucleotide
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Wip1 (protein phosphatase Mg(2+)/Mn(2+)-dependent 1D, Ppm1d) is a nuclear serine/threonine protein phosphatase that is induced by p53 following the activation of DNA damage response (DDR) signaling. Ppm1d(-/-) mouse embryonic fibroblasts (MEFs) exhibit premature senescence under conventional culture conditions; however, little

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