A3109

A-803467

≥98% (HPLC)

• Sinonimo/i: 5-4(-Chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-carboxamide
• Formula empirica (notazione di Hill): C₁₉H₁₆NO₄Cl
• Numero CAS: 944261-79-4
• Peso molecolare: 357.79
• Numero MDL: MFCD10574689
• Codice UNSPSC: 12352200
• ID PubChem: 329770815
• NACRES: NA.77

Proprietà

• Saggio: ≥98% (HPLC)
• Forma fisica: powder
• Colore: white to tan
• Solubilità: DMSO: >10 mg/mL
• Ideatore: Abbott
• Temperatura di conservazione: room temp
• Stringa SMILE: COc1cc(NC(=O)c2ccc(o2)-c3ccc(Cl)cc3)cc(OC)c1
• InChI: 1S/C19H16ClNO4/c1-23-15-9-14(10-16(11-15)24-2)21-19(22)18-8-7-17(25-18)12-3-5-13(20)6-4-12/h3-11H,1-2H3,(H,21,22); VHKBTPQDHDSBSP-UHFFFAOYSA-N

Descrizione

Descrizione generale

A-803467 inhibits spontaneous and evoked action potentials in sensory neurons. It exhibits antinociceptive effects. A-803467 decreases the firing in spinal dorsal horn neurons in vivo.

The small molecule A-803467 is a potent and selective Nav1.8 sodium channel blocker. Nav1.8 is a tetrodotoxin-resistant (TTX-R) sodium channel that contributes to pain sensation by transmitting pain stimuli in peripheral sensory neurons; blockage of this channel by A-803467 reduces pain with varying effectiveness in a number of different models. A-803467 has been used to further understand the role of Nav1.8 in transmitting pain stimuli and also can be used as an analgesic.

Azioni biochim/fisiol

A-803467 blocks Nav1.8 in both half-maximal inactive and resting states with an IC₅₀ of 8 nM and IC₅₀ of 79 nM, respectively. A-803467 is over 100-fold more selective vs. human Nav1.2, 1.3, 1.5 and 1.7.

Caratteristiche e vantaggi

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable