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A2201

Sigma-Aldrich

Amyloid β-Protein Fragment 35-25

≥95% (HPLC)

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About This Item

Formula empirica (notazione di Hill):
C45H81N13O14S
Numero CAS:
147740-73-6
Peso molecolare:
1060.27
Numero MDL:
MFCD00214225
Codice UNSPSC:
51111800
ID PubChem:
24890634
NACRES:
NA.32

Livello qualitativo

200

Saggio

≥95% (HPLC)

Forma fisica

powder

N° accesso UniProt

P05067

Temperatura di conservazione

−20°C

Stringa SMILE

CCC(C)C(NC(=O)CNC(=O)C(CC(C)C)NC(=O)C(N)CCSC)C(=O)NC(C(C)CC)C(=O)NC(C)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CC(N)=O)C(=O)NC(CO)C(=O)NCC(O)=O

InChI

1S/C45H81N13O14S/c1-9-24(5)36(57-34(62)20-50-40(67)29(17-23(3)4)54-39(66)27(47)14-16-73-8)45(72)58-37(25(6)10-2)44(71)52-26(7)38(65)49-19-33(61)53-28(13-11-12-15-46)42(69)55-30(18-32(48)60)43(70)56-31(22-59)41(68)51-21-35(63)64/h23-31,36-37,59H,9-22,46-47H2,1-8H3,(H2,48,60)(H,49,65)(H,50,67)(H,51,68)(H,52,71)(H,53,61)(H,54,66)(H,55,69)(H,56,70)(H,57,62)(H,58,72)(H,63,64)
IDGOADDOQWKZOX-UHFFFAOYSA-N

Informazioni sul gene

human ... APP(351)

Amino Acid Sequence

Met-Leu-Gly-Ile-Ile-Ala-Gly-Lys-Asn-Ser-Gly

Descrizione generale

Amyloid β precursor protein (APP) is a type-1 transmembrane protein. APP is expressed widely and mainly found in the synapses and neurons. The APP gene is mapped to human chromosome 21q21.3.

Applicazioni

Amyloid β-Protein Fragment 35-25 has been used as a control peptide for Aβ-induced apoptosis to study the role of hepcidin overexpression in astrocytes against amyloid-β induced brain damage in mice.

Azioni biochim/fisiol

Proteolytic processing of amyloid β precursor protein (APP) forms the β amyloid protein (Aβ) as part of the brain amyloid plaques which are the key biomarkers in Alzheimer′s disease. APP is known to be associated with neurogenesis, synapse formation, axonal transport, neuronal migration and neurite outgrowth. It is also related to mitochondria-associated endoplasmic reticulum membranes (MAMs) activity, antimicrobial protection, cholesterol, and iron homeostasis. Amyloid β-Protein Fragment 35-25 is an inactive control.

Altre note

The N—C inverted sequence of fragment 25-35

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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Sigma-Aldrich

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Mechanisms of ageing and development, 196, 111477-111477 (2021-04-03)
Emerging evidence from experimental and clinical research suggests that stress-related genes may play key roles in AD development. The fact that genome-wide association studies were not able to detect a contribution of such genes to AD indicates the possibility that
Jasmine Chebli et al.
Scientific reports, 11(1), 19115-19115 (2021-09-29)
Amyloid precursor protein (APP) is expressed in many tissues in human, mice and in zebrafish. In zebrafish, there are two orthologues, Appa and Appb. Interestingly, some cellular processes associated with APP overlap with cilia-mediated functions. Whereas the localization of APP
Alzheimer's disease: amyloid beta-peptide antibody vaccine as plaque remover.
A Kumar
Journal of biosciences, 25(4), 315-316 (2000-12-20)
Elvis Cuevas et al.
Metabolic brain disease, 34(5), 1365-1374 (2019-07-04)
The amyloid β-peptide (Aβ) is transported across the blood-brain barrier (BBB) by binding with the receptor for advanced glycation end products (RAGE). Previously, we demonstrated that the Aβ fraction 25-35 (Aβ25-35) increases RAGE expression in the rat hippocampus, likely contributing
B A Yankner et al.
Science (New York, N.Y.), 250(4978), 279-282 (1990-10-12)
The amyloid beta protein is deposited in the brains of patients with Alzheimer's disease but its pathogenic role is unknown. In culture, the amyloid beta protein was neurotrophic to undifferentiated hippocampal neurons at low concentrations and neurotoxic to mature neurons
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