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A0887

Sigma-Aldrich

5α-Androstane

Sinonimo/i:

Etioallocholane

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About This Item

Formula empirica (notazione di Hill):
C19H32
Numero CAS:
438-22-2
Peso molecolare:
260.46
Numero CE:
207-116-2
Numero MDL:
MFCD00067600
Codice UNSPSC:
12352211
ID PubChem:
24890466
NACRES:
NA.77
Stato:
powder
Saggio:
≥99% (HPLC)

Saggio

≥99% (HPLC)

Livello qualitativo

200

Stato

powder

Solubilità

chloroform: 49-51 mg/mL, clear, colorless

Condizioni di spedizione

ambient

Temperatura di conservazione

room temp

Stringa SMILE

[H][C@@]12CC[C@@]3([H])CCCC[C@]3(C)[C@@]1([H])CC[C@]4(C)CCC[C@@]24[H]

InChI

1S/C19H32/c1-18-11-5-7-16(18)15-9-8-14-6-3-4-12-19(14,2)17(15)10-13-18/h14-17H,3-13H2,1-2H3/t14-,15+,16+,17+,18+,19+/m1/s1
QZLYKIGBANMMBK-UGCZWRCOSA-N

Informazioni sul gene

human ... UGT1A4(54657)

Applicazioni

5α-Androstane has been used to treat androgen-dependent and androgen-independent prostate cancer cells (LNCaP and PC-3) to investigate cell proliferation, viability, adhesion and hormone expression.

Altre note

Serves as the parent steroid skeleton for all androgens, but the hydrocarbon itself is not naturally occurring.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
089M4091V
13180806
058M4067V
13171110
018M4101V

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Sigma-Aldrich

176591

Anthracene-d10

5α-Androstan-17β-ol-3-one purum, ≥99.0% (TLC)

Sigma-Aldrich

10300

5α-Androstan-17β-ol-3-one

C8-C40 Alkanes Calibration Standard in dichloromethane (varied)

Supelco

40147-U

C8-C40 Alkanes Calibration Standard

Estrogen and androgen hormone levels modulate the expression of PIWI interacting RNA in prostate and breast cancer
Oner C, et al.
PLoS ONE, 11(7), e0159044-e0159044 (2016)
Haodong Ji et al.
Marine pollution bulletin, 135, 427-440 (2018-10-12)
Oil degradation by surface-level atmospheric ozone has been largely ignored in the field. To address this knowledge gap, this study investigated the ozonation rate and extent of typical petroleum compounds by simulated surface-level ozone, including total petroleum hydrocarbons (TPHs), n-alkanes
Kaoru Kobayashi et al.
Drug metabolism and disposition: the biological fate of chemicals, 33(7), 924-929 (2005-04-02)
Constitutive active (or androstane) receptor (CAR, NR1I3), a member of the nuclear receptor family, is a major regulator for induction of cytochrome P450 2B (CYP2B) genes by phenobarbital. Phenobarbital-like inducer, 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is a potent mouse CAR ligand that has been
Nathan J Cherrington et al.
The Journal of pharmacology and experimental therapeutics, 300(1), 97-104 (2001-12-26)
Many phase I and II microsomal enzyme inducers share common mechanisms of transcriptional activation and thus share a similar battery of genes that are coordinately regulated. Many phase II metabolites are thought to be transported out of cells by multidrug
Neelima Dhingra et al.
Archives of pharmacal research, 34(7), 1055-1063 (2011-08-04)
A number of 17-oxo-5-androsten-3β-yl esters (9a-9f) and 3β-alkoxy-5-androsten-17-ones (11a-11e) were synthesized from commercially available (25R)-5-spirosten-3β-ol (Diosgenin) (4) as starting material. The synthesized compounds were evaluated for their antiproliferative activity against the prostate-specific cancer cell line DU-145, acute toxicity and effect
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