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Key Documents

82870

Sigma-Aldrich

Pyridoxal 5′-phosphate monohydrate

≥97.0% (NT)

Sinonimo/i:

P5P, 3-Hydroxy-2-methyl-5-([phosphonooxy]methyl)-4-pyridinecarboxaldehyde, Codecarboxylase, PLP, Pyridoxal 5-phosphate

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About This Item

Formula empirica (notazione di Hill):
C8H10NO6P · H2O
Numero CAS:
Peso molecolare:
265.16
Beilstein:
234749
Numero MDL:
Codice UNSPSC:
12352204
ID PubChem:
NACRES:
NA.51

Origine biologica

synthetic

Livello qualitativo

Saggio

≥97.0% (NT)

Forma fisica

powder

tecniche

enzyme immunoassay: suitable

Colore

white to light yellow

Punto di fusione

140-143 °C (lit.)

Anioni in tracce

chloride (Cl-): ≤500 mg/kg
sulfate (SO42-): ≤50 mg/kg

Cationi in tracce

Ca: ≤20 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤50 mg/kg
K: ≤50 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Na: ≤2000 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Zn: ≤5 mg/kg

applicazioni

cell analysis

Temperatura di conservazione

2-8°C

Stringa SMILE

O=CC1=C(C(C)=NC=C1COP(O)(O)=O)O.[OH]

InChI

1S/C8H10NO6P.H2O/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14;/h2-3,11H,4H2,1H3,(H2,12,13,14);1H2
CEEQUQSGVRRXQI-UHFFFAOYSA-N

Descrizione generale

Pyridoxal 5′-phosphate (PLP), an active form of vitamin B6/ pyridoxine is the coenzyme of amino acid metabolism.

Applicazioni

Pyridoxal 5′-phosphate monohydrate has been used:
  • as a component in the reaction mixture for ornithine decarboxylase (ODC) activity assay
  • as a standard to quantify the concentration of pyridoxal 5′-phosphate (PLP) in cerebrospinal fluid (CSF) of children
  • as a dietary supplement to study its effects on the lethal phenotype of mutant flies

Azioni biochim/fisiol

Pyridoxine participates in the production of lipid and neurotransmitters. Pyridoxal 5′-phosphate (PLP) serves as a cofactor to stabilize carbanions at Cα of amino acids. Pyridoxine deficiency results in peripheral neuropathy. Absence of PLP leads to neonatal epileptic encephalopathy. PLP acts as a coenzyme in transamination, decarboxylation and deamination reactions such as the conversion of dopa into dopamine; of glutamate into γ aminobutyric acid (GABA); of histidine to histamine. PLP works mechanistically through formation of a Schiff-base.

Altre note

Coenzymes and Cofactors, vol. 1: Vitamin B6, Pyridoxal Phosphate

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)


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