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44001

Sigma-Aldrich

N-Acetyl-D-glucosamin-6-sulfat

≥98.0% (TLC)

Sinonimo/i:

GlcNAc-6S

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About This Item

Formula condensata:
C8H14NO9SNa
Numero CAS:
108321-79-5
Peso molecolare:
323.25
Numero MDL:
MFCD00063415
Codice UNSPSC:
12352201
ID PubChem:
329756440
NACRES:
NA.25

Origine biologica

synthetic

Livello qualitativo

100

Descrizione

Mixed anomers

Saggio

≥98.0% (TLC)

Forma fisica

solid

Attività ottica

[α]20/D 32.0±2.0, c = 0.1% (w/v) in water

tecniche

thin layer chromatography (TLC): suitable

Colore

colorless

Temperatura di conservazione

−20°C

Stringa SMILE

[Na+].CC(=O)N[C@H]1C(O)O[C@H](COS([O-])(=O)=O)[C@@H](O)[C@@H]1O

InChI

1S/C8H15NO9S.Na/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16;/h4-8,11-13H,2H2,1H3,(H,9,10)(H,14,15,16);/q;+1/p-1/t4-,5-,6-,7-,8?;/m1./s1
CBUJZKTVEFVBBG-FROKLYQUSA-M

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Applicazioni

N-Acetyl-D-glucosamine 6-sulfate (GlcNAc-6S) is used as a substrate and inhibitor to identify, differentiate and characterize various sulfatase(s), especially N-acetylglucosamine-6-sulphatase(s).

Confezionamento

Bottomless glass bottle. Contents are inside inserted fused cone.

Altre note

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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N H Elçioglu et al.
Genetic counseling (Geneva, Switzerland), 20(2), 133-139 (2009-08-05)
A novel loss-of-function mutation in the GNS gene causes Sanfilippo syndrome type D: Mucopolysaccharidosis type IIID (MIM 252940) is the least common form of the four subtypes of Sanfilippo syndrome. It is an autosomal recessive lysosomal disorder caused by a
Shengyuan Xu et al.
The Biochemical journal, 387(Pt 3), 841-847 (2004-12-15)
A 75 kDa protein was purified to homogeneity from granule extracts of normal human granulocytes using Sephadex G-75 chromatography, Mono-S cation exchange chromatography and chromatofocusing. The protein consisted of one chain with a molecular mass of 75 kDa, as determined
Andrew J Nok et al.
Journal of biochemical and molecular toxicology, 17(1), 59-66 (2003-03-05)
The venom of Naja nigricolis was found to contain a high level of the enzyme aryl sulfatase. The enzyme was isolated from the venom of N. nigriclois and purified to electrophoretic homogeneity by gel chromatography on Sephadex G-100, DEAE-cellulose, and
Andrea Mok et al.
Genomics, 81(1), 1-5 (2003-02-08)
Mucopolysaccharidosis type IIID (MPS IIID; Sanfilippo syndrome type D; MIM 252940) is caused by deficiency of the activity of N-acetylglucosamine-6-sulfatase (GNS), which is normally required for degradation of heparan sulfate. The clinical features of MPS IIID include progressive neurodegeneration, with

Articoli

Glycosaminoglycan Sulfation and Signaling

Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.

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