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Documenti fondamentali

303M-1

Sigma-Aldrich

Cytokeratin, HMW (AE3) Mouse Monoclonal Antibody

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

mouse

Livello qualitativo

100
500

Coniugato

unconjugated

Forma dell’anticorpo

culture supernatant

Tipo di anticorpo

primary antibodies

Clone

AE3, monoclonal

Descrizione

For In Vitro Diagnostic Use in Select Regions (See Chart)

Stato

buffered aqueous solution

Reattività contro le specie

human

Confezionamento

vial of 0.1 mL concentrate (303M-14)
vial of 0.5 mL concentrate (303M-15)
bottle of 1.0 mL predilute (303M-17)
vial of 1.0 mL concentrate (303M-16)
bottle of 7.0 mL predilute (303M-18)

Produttore/marchio commerciale

Cell Marque®

tecniche

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

Isotipo

IgG1κ

Controllo

prostate

Condizioni di spedizione

wet ice

Temperatura di conservazione

2-8°C

Visualizzazione

cytoplasmic

Informazioni sul gene

human ... KRT1(3848)

Categorie correlate

Descrizione generale

Anti-cytokeratin, high molecular weight (AE3) is capable of recognizing all basic keratins; therefore, it is a broadly reactive antibody staining most epithelia and their neoplasms. Members of the acidic and basic subfamilies are found together in pairs. Since each epithelium contains at least one acidic and one basic keratin, this antibody is used to observe the distribution of keratin-containing cells in normal epithelia and to identify neoplasms derived from such epithelium.

Qualità


IVD
IVD
IVD
RUO

Linkage

Cytokeratin, HMW Positive Control Slides, Product No. 303S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Stato fisico

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Nota sulla preparazione

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Altre note

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Note legali

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
0000288452
0000287222
0000288452
0000287222

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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

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W G Nelson et al.
Cancer research, 44(4), 1600-1603 (1984-04-01)
The expression of specific keratin polypeptides in human neoplasms was investigated by the immunoblot technique using monoclonal anti-keratin antibodies. Mr 50,000 and 58,000 keratins, recognized by AE1 and AE3 antibodies, respectively, were detected only in carcinomas of stratified epithelial origin
V Eusebi et al.
The American journal of surgical pathology, 14(8), 737-747 (1990-08-01)
We present four cases of a malignant thyroid tumor showing morphologic, immunocytochemical, and ultrastructural features of endothelial cell differentiation. The tumor cells had epithelioid features and displayed strong immunoreactivity for keratin. There was no evidence of follicular or C-cell differentiation
A Lopez-Beltrán et al.
Virchows Archiv : an international journal of pathology, 438(6), 552-557 (2001-07-27)
Lymphoepithelioma-like carcinoma (LELCA) of the urinary bladder is a rare variant of bladder cancer characterized by a malignant epithelial component densely infiltrated by lymphoid cells. It is characterized by indistinct cytoplasmic borders and a syncytial growth pattern. These neoplasms deserve
R A Weiss et al.
The Journal of cell biology, 98(4), 1397-1406 (1984-04-01)
The polypeptide composition of epidermal keratin varies in disease. To better understand the biological meaning of these variations, we have analyzed keratins from a number of human epidermal diseases by the immunoblot technique using AE1 and AE3 monoclonal antikeratin antibodies.
Monoclonal antibody studies of mammalian epithelial keratins: a review.
T T Sun et al.
Annals of the New York Academy of Sciences, 455, 307-329 (1985-01-01)
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