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Y0000851

Doxepin for system suitability

European Pharmacopoeia (EP) Reference Standard

Sinonimo/i:

Doxepin hydrochloride, 11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepine hydrochloride

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About This Item

Formula empirica (notazione di Hill):
C19H21NO · HCl
Numero CAS:
1229-29-4
Peso molecolare:
315.84
Numero MDL:
MFCD00079135
Codice UNSPSC:
41116107
ID PubChem:
329831189
NACRES:
NA.24

Grado

pharmaceutical primary standard

Famiglia di API

doxepin

Produttore/marchio commerciale

EDQM

applicazioni

pharmaceutical (small molecule)

Formato

neat

Temperatura di conservazione

2-8°C

Stringa SMILE

Cl[H].CN(C)CC\C=C1/c2ccccc2COc3ccccc13

InChI

1S/C19H21NO.ClH/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19;/h3-6,8-12H,7,13-14H2,1-2H3;1H/b17-11+;
MHNSPTUQQIYJOT-SJDTYFKWSA-N

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Descrizione generale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Applicazioni

Doxepin for system suitability EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Confezionamento

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Altre note

Sales restrictions may apply.

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1225500

Doxepin hydrochloride, United States Pharmacopeia (USP) Reference Standard

1225522

Doxepin Related Compound B, United States Pharmacopeia (USP) Reference Standard

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Doxepin Related Compound C, United States Pharmacopeia (USP) Reference Standard

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Doxepin hydrochloride, British Pharmacopoeia (BP) Reference Standard

BP823

Doxepin impurity standard, British Pharmacopoeia (BP) Reference Standard

PHR8923

Doxepin Related Compound C

PHR8924

Doxepin Related Compound B, Pharmaceutical Secondary Standard; Certified Reference Material

Pittogrammi

Skull and crossbones
GHS06

Avvertenze

Danger

Indicazioni di pericolo

H301

Consigli di prudenza

P301 + P330 + P331 + P310

Classi di pericolo

Acute Tox. 3 Oral

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number

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Andrew D Krystal et al.
Sleep, 34(10), 1433-1442 (2011-10-04)
To evaluate the efficacy and safety of doxepin (DXP) 3 mg and 6 mg in adults diagnosed with primary insomnia. The study was a randomized, double-blind, parallel-group, placebo-controlled trial. Patients meeting DSM-IV-TR criteria for primary insomnia were randomized to 35
Anna Maślanka et al.
Journal of AOAC International, 94(6), 1791-1799 (2012-02-11)
Stability of clonazepam, diazepam, haloperidol, and doxepin was determined in acidic solutions. In addition, determination of the kinetic and thermodynamic properties of this stability was carried out. Reaction rate constants (k), half-life times (t(0.1) and t(0.5)), and activation energy (Ea)
Alan Lankford et al.
Sleep medicine, 13(2), 133-138 (2011-12-27)
The efficacy and safety of doxepin (DXP), a histamine H(1) receptor antagonist, was evaluated in elderly adults with sleep maintenance insomnia. This was a randomized, double-blind, placebo-controlled outpatient trial. Elderly adults meeting DSM-IV-TR criteria for primary insomnia were randomized to
Christopher J Jones et al.
Analytical chemistry, 84(16), 7099-7106 (2012-08-03)
The capillary isotachophoresis (cITP) separation of the isomers of the tricyclic antidepressant doxepin using β-cyclodextrin (β-CD) as a buffer additive is investigated by online microcoil NMR detection. Capillary electrophoresis (CE) is also used to determine the binding constant between the
Hancheng Cai et al.
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, 14(5), 546-552 (2012-01-10)
(11)C-Doxepin is an established positron emission tomography (PET) probe for imaging the histamine H1 receptor, which is associated with various neurological disorders and allergic diseases. A fully automated current Good Manufacturing Practices (cGMP)-compliant radiosynthesis is therefore desirable in order to
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