SBR00025
Novobiocin Ready Made Solution
100 mg/mL in water
Sinonimo/i:
Novobiocin Ready Made Solution
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About This Item
Formula condensata:
C31H35N2NaO11
Peso molecolare:
634.61
Codice UNSPSC:
51286504
NACRES:
NA.76
Prodotti consigliati
Origine biologica
microbial
Saggio
≥90%
Forma fisica
liquid
Concentrazione
100 mg/mL in water
Colore
faint yellow to dark brown
Spettro attività antibiotica
Gram-negative bacteria
Gram-positive bacteria
mycobacteria
neoplastics
Modalità d’azione
DNA synthesis | interferes
enzyme | inhibits
Temperatura di conservazione
−20°C
Descrizione generale
Novobiocin, also known as albamycin or cathomycin, is an aminocoumarin antibiotic commonly derived from Streptomyces Sp. It exerts its antibacterial activity by inhibiting Topo II α, which corresponds to bacterial DNA gyrase. It is effective against both gram-positive and gram-negative bacteria and is significant in research involving highly beta-lactam-resistant pneumococcal infections and anti-orthopoxvirus applications. Functioning as a competitive inhibitor in the ATPase reaction catalyzed by GyrB, Novobiocin is employed in microbiology and cell biology research to effectively prevent the growth of bacterial contaminants.
Applicazioni
Novobiocin has been used:
- in cell culture systems to treat mycoplasma contaminations.[3]
- in a research to where it has exhibited anti-cancer effects by inhibition of Hsp90 (heat shock protein)[4],[5]
Azioni biochim/fisiol
Mode of Action: Inhibits DNA synthesis by inhibiting the enzyme Topoisomerase II
Activity spectrum: Active against gram-positive and gram-negative bacteria
Activity spectrum: Active against gram-positive and gram-negative bacteria
Caratteristiche e vantaggi
- Ready available solution reduce the need for preparation time
- Commonly used in Cell Biology and Biochemical applications
- High quality antibiotic suitable for mulitple research applications
Nota sulla preparazione
Novobiocin Ready Made Solution is light sensitive. Thaw this product at room temperature. It is recommended to avoid repeated freeze thaw cycles of this product. The suggested concentration of Novobiocin for cell culture assays is 50-1000 μg/mL,,, therefore, it is recommended to dilute the Ready Made Solution 1:100-2000.
Altre note
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Avvertenze
Warning
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Skin Sens. 1
Codice della classe di stoccaggio
12 - Non Combustible Liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Environmentally constrained mutation and adaptive evolution in Salmonella.
Massey, R. C., Rainey, P. B., Sheehan, B. J., Keane, O. M., & Dorman, C. J.
Current Biology, 9, 1477-1481 (1999)
Biosynthesis of novobiocin by Streptomyces niveus.
Kominek, L. A.
Antimicrobial Agents and Chemotherapy, 1, 123-134 (1972)
Synthesis and biological evaluation of arylated novobiocin analogs as Hsp90 inhibitors.
Kusuma, B. R., Duerfeldt, A. S., & Blagg, B. S.
Bioorganic & Medicinal Chemistry Letters, 21, 7170-7174 (2011)
Mycoplasmas in tissue culture.
Macpherson, I.
Journal of Cell Science, 1, 145-168 (1966)
Novobiocin antagonism of amastigotes of Trypanosoma cruzi growing in cell-free medium.
Pate, P. G., Wolfson, J. S., McHugh, G. L., Pan, S. C., & Swartz, M. N.
Antimicrobial Agents and Chemotherapy, 29, 426-431 (1986)
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