S0252

Sulfobromophthalein disodium salt hydrate

used to study hepatocyte transport functions

• Sinonimo/i: BSP, Bromsulfalein sodium disodium salt hydrate
• Formula empirica (notazione di Hill): C₂₀H₈Br₄Na₂O₁₀S₂ · xH₂O
• Numero CAS: 123359-42-2
• Peso molecolare: 838.00 (anhydrous basis)
• Numero CE: 200-761-0
• Numero MDL: MFCD00150017
• Codice UNSPSC: 12171500
• ID PubChem: 24899433
• NACRES: NA.47

Proprietà

• Livello qualitativo: 200
• Stato: powder
• Composizione: Water (by Karl Fischer): ≤ 8%; ; Sodium (Na) anhydrous: 4.6-5.8%
• tecniche: titration: suitable
• Colore: white to light gray
• Solubilità: water: 50 mg/mL, clear to hazy
• λmax: 575-581 nm
• applicazioni: diagnostic assay manufacturing; hematology; histology
• Temperatura di conservazione: room temp
• Stringa SMILE: [Na+].[Na+].[H]O[H].Oc1ccc(cc1S([O-])(=O)=O)C2(OC(=O)c3c(Br)c(Br)c(Br)c(Br)c23)c4ccc(O)c(c4)S([O-])(=O)=O
• InChI: 1S/C20H10Br4O10S2.2Na.H2O/c21-15-13-14(16(22)18(24)17(15)23)20(34-19(13)27,7-1-3-9(25)11(5-7)35(28,29)30)8-2-4-10(26)12(6-8)36(31,32)33;;;/h1-6,25-26H,(H,28,29,30)(H,31,32,33);;;1H2/q;2*+1;/p-2; CDTNUNQQEUGDSD-UHFFFAOYSA-L

Descrizione

Applicazioni

Sulfobromophthalein disodium salt hydrate has been used as a positive control to study the interaction of 11-keto-β-boswellic acid (KBA) and 3-acetyl-11-keto-β-boswellic acid (AKBA) with organic anion transporter OATP1B3.

Azioni biochim/fisiol

Sulfobromophthalein (BSP) is a high affinity organic ion substrate for organic anion transporting polypeptides (OATPs) and has been used as a substrate for multidrug resistance associated protein 2 (Mrp2). BSP is transported into hepatocytes by OATPs and, after conjugation to glutathione, is excreted into bile by Mrp2. It was found to inhibit the aldo-keto reductase ARK1C20.

Informazioni sulla sicurezza

• Pittogrammi: GHS08
• Avvertenze: Danger
• Indicazioni di pericolo: H317,H334
• Consigli di prudenza: P261 - P280 - P342 + P311
• Classi di pericolo: Resp. Sens. 1 - Skin Sens. 1
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Faceshields, Gloves