PHR1403

Phentolamine Mesylate

Pharmaceutical Secondary Standard; Certified Reference Material

• Sinonimo/i: Phentolamine methanesulfonate salt, 2-(N-[m-Hydroxyphenyl]-p-toluidinomethyl)imidazoline
• Formula condensata: C₁₇H₁₉N₃O · CH₃SO₃H
• Numero CAS: 65-28-1
• Peso molecolare: 377.46
• Numero CE: 200-604-6
• Numero MDL: MFCD00134201
• Codice UNSPSC: 41116107
• ID PubChem: 329823376
• NACRES: NA.24

Proprietà

• Grado: certified reference material; pharmaceutical secondary standard
• Livello qualitativo: 300
• agenzia: traceable to Ph. Eur. Y0001127; traceable to USP 1530004
• Famiglia di API: phentolamine
• CdA: current certificate can be downloaded
• tecniche: HPLC: suitable; gas chromatography (GC): suitable
• Punto di fusione: 180-182 °C (lit.)
• applicazioni: pharmaceutical (small molecule)
• Formato: neat
• Temperatura di conservazione: 2-30°C
• Stringa SMILE: CS(O)(=O)=O.Cc1ccc(cc1)N(CC2=NCCN2)c3cccc(O)c3
• InChI: 1S/C17H19N3O.CH4O3S/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15;1-5(2,3)4/h2-8,11,21H,9-10,12H2,1H3,(H,18,19);1H3,(H,2,3,4); OGIYDFVHFQEFKQ-UHFFFAOYSA-N
• Informazioni sul gene: human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146) , ADRA2A(150) , ADRA2B(151) , ADRA2C(152)

Descrizione

Descrizione generale

Phentolamine Mesylate belongs to the class of alpha adrenergic antagonist drugs. It is used in the treatment of pheochromocytoma-related hypertension, erectile dysfunction and in the diagnosis of pheochromocytoma and norepinephrine-related dermal necrosis.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Applicazioni

Phentolamine Mesylate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chemiluminescence technique.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Azioni biochim/fisiol

α-Adrenergic receptor antagonist; peripheral vasodilator.

Risultati analitici

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Altre note

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota a piè di pagina

To see an example of a Certificate of Analysis for this material enter LRAC3261 in the slot below. This is an example certificate only and may not be the lot that you receive.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302,H315,H319,H335
• Consigli di prudenza: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Classi di pericolo: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organi bersaglio: Respiratory system
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable