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N0500000

Neostigmine bromide

European Pharmacopoeia (EP) Reference Standard

Sinonimo/i:

3-(N,N-Dimethylcarbamoyloxy)-N,N,N,-trimethylanilinium bromide, Prostigmine

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About This Item

Formula empirica (notazione di Hill):
C12H19BrN2O2
Numero CAS:
114-80-7
Peso molecolare:
303.20
Numero MDL:
MFCD00011795
Codice UNSPSC:
41116107
ID PubChem:
329818440
NACRES:
NA.24

Grado

pharmaceutical primary standard

Famiglia di API

neostigmine

Produttore/marchio commerciale

EDQM

applicazioni

pharmaceutical (small molecule)

Formato

neat

Temperatura di conservazione

2-8°C

Stringa SMILE

[Br-].CN(C)C(=O)Oc1cccc(c1)[N+](C)(C)C

InChI

1S/C12H19N2O2.BrH/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5;/h6-9H,1-5H3;1H/q+1;/p-1
LULNWZDBKTWDGK-UHFFFAOYSA-M

Informazioni sul gene

human ... ACHE(43)

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Descrizione generale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Applicazioni

Neostigmine bromide EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Azioni biochim/fisiol

Reversible inhibitor of acetylcholinesterase that is similar to eserine, but does not cross the blood-brain barrier.

Confezionamento

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Altre note

Sales restrictions may apply.

Pittogrammi

Skull and crossbonesHealth hazard
GHS06,GHS08

Avvertenze

Danger

Classi di pericolo

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Lot/Batch Number

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Jessica Kåhlin et al.
Experimental physiology, 99(8), 1089-1098 (2014-06-03)
Studies on experimental animals established that the carotid bodies are sensory organs for detecting arterial blood O2 levels and that the ensuing chemosensory reflex is a major regulator of cardiorespiratory functions during hypoxia. However, little information is available on the
Seham Mustafa et al.
Urology, 84(6), 1549-1549 (2014-12-03)
To examine the effects of neostigmine, an acetylcholinesterase inhibitor that has been used to treat impaired bladder emptying on diabetic rat urinary bladder smooth muscle. Rat urinary detrusor muscle strips were suspended in organ baths containing Krebs' solution for isometric
Machika Moriya et al.
Masui. The Japanese journal of anesthesiology, 63(4), 418-422 (2014-05-03)
We experienced severe asthmatic crisis during general anesthesia in a 45-year-old man with IgG4-related disease, COPD and athma undergoing removal of submandibular gland. The ventilatiory failure was caused by the stimulation of the operation, sputum, and neostigmine. His serum IgG4
Su-Hsun Liu et al.
Clinical toxicology (Philadelphia, Pa.), 53(1), 13-21 (2014-11-21)
Pufferfish-associated tetrodotoxin poisoning occurs occasionally in coastal regions of Asian countries and sporadically elsewhere. While anecdotal reports have suggested neostigmine use, evidence for its clinical effectiveness remains unclear. We sought to determine whether neostigmine was likely to be effective in
H S Bawaskar et al.
Tropical doctor, 44(2), 82-85 (2014-02-20)
Between January 2005 and August 2011 141 victims of krait bite poisoning were admitted to the general hospital at Mahad. Clinical signs and symptoms preceding the development of neuroparalysis were analyzed. Fifty-six percent of patients were male. A total of
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