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M8506

Supelco

Methimazole

analytical standard

Sinonimo/i:

1-Methyl-2-mercaptoimidazole, MET, 1-Methyl-2-imidazolethiol, 2-Mercapto-1-methylimidazole

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About This Item

Formula empirica (notazione di Hill):
C4H6N2S
Numero CAS:
60-56-0
Peso molecolare:
114.17
Beilstein:
108646
Numero CE:
200-482-4
Numero MDL:
MFCD00179321
Codice UNSPSC:
41116107
eCl@ss:
39161002
ID PubChem:
329818061
NACRES:
NA.24

Grado

analytical standard

Livello qualitativo

200

Saggio

≥99%

tecniche

HPLC: suitable
gas chromatography (GC): suitable

Punto di fusione

144-147 °C (lit.)

applicazioni

cleaning products
cosmetics
food and beverages
forensics and toxicology
personal care
pharmaceutical (small molecule)
veterinary

Formato

neat

Stringa SMILE

CN1C=CNC1=S

InChI

1S/C4H6N2S/c1-6-3-2-5-4(6)7/h2-3H,1H3,(H,5,7)
PMRYVIKBURPHAH-UHFFFAOYSA-N

Informazioni sul gene

human ... TPO(7173)

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Descrizione generale

Methimazole belongs to the chemical class of thioureylene compounds, used as an anti-thyroid drug in the management of hyperthyroidism.

Applicazioni

Beclomethasone dipropionate analytical standard can be used as follows:

  • Silver/graphene-modified carbon-paste electrode (AgGCPE) based electrochemical determination of methimazole
  • Development of a surface-enhanced Raman scattering (SERS) based method to estimate propylthiouracil and methimazole using sodium alginate-protected silver nanoparticles as SERS substrate
  • Detection of methimazole at ultra-trace limits using surface-enhanced Raman spectroscopy based on gold nanoparticles (AuNPs) substrate
  • Quantitative analysis of human blood samples for methimazole using high-performance liquid chromatography-tandem mass spectrometric (HPLC-MS/MS) method
  • Electrochemical determination of methimazole in pharmaceutical tablet and human blood serum samples by molecularly imprinted polymer (MIP)- pencil graphite electrode (PGE) based sensor

Altre note

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pittogrammi

Health hazardExclamation mark
GHS08,GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302,H317,H319,H361fd

Classi di pericolo

Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2 - Skin Sens. 1

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Scegli una delle versioni più recenti:

Certificati d'analisi (COA)

Lot/Batch Number
WXBD6479V
WXBD5793V
WXBD4906V
WXBD4215V
WXBD3839V

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Sigma-Aldrich

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Supelco

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USP

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Supelco

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Sigma-Aldrich

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Pronase® Protease, Streptomyces griseus

Millipore

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Determination of methimazole in urine with the iodine-azide detection system following its separation by reversed-phase high-performance liquid chromatography
Zakrzewski R
Journal of Chromatography. B, Biomedical Applications, 869(1-2), 67-74 (2008)
MMSPE-RP-HPLC method for the simultaneous determination of methimazole and selected metabolites in fish homogenates.
Hollosi L, et al.
Journal of Pharmaceutical and Biomedical Analysis, 36(4), 921-924 (2004)
Francesco Isaia et al.
Journal of medicinal chemistry, 51(13), 4050-4053 (2008-06-06)
The antithyroid drug methimazole (MMI) reacts with molecular iodine to form, in a multistep process, 1-methylimidazole as final product. In this process, the charge transfer complex MMI-I 2 and the ionic disulfide [(C 4H 6N 2S-) 2] (2+) ( 1
Coralie Leblicq et al.
Pediatrics, 131(2), e616-e619 (2013-01-09)
A 15-year-old girl presented with chorea as a first sign of Graves' hyperthyroidism. Chorea abated with antithyroid drug treatment and reappeared when hyperthyroidism recurred but not when thyrotropin receptor antibodies increased after administration of (131)I. Therefore, chorea in this patient
F S Boretti et al.
Journal of veterinary internal medicine, 27(2), 377-381 (2013-02-13)
Transdermal methimazole is an acceptable alternative to oral treatment for hyperthyroid cats. There are, however, no studies evaluating the duration of T4 suppression after transdermal methimazole application. Such information would be valuable for therapeutic monitoring. To assess variation in serum
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