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Supelco

Leptophos

PESTANAL®, analytical standard

Sinonimo/i:

O-(4-Bromo-2,5-dichlorophenyl) O-methyl phenylphosphonothioate

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About This Item

Formula empirica (notazione di Hill):
C13H10BrCl2O2PS
Numero CAS:
21609-90-5
Peso molecolare:
412.07
Beilstein:
2152663
Numero CE:
244-472-8
Numero MDL:
MFCD00128037
Codice UNSPSC:
41116107
ID PubChem:
329754497
NACRES:
NA.24

Grado

analytical standard

Nome Commerciale

PESTANAL®

Durata

limited shelf life, expiry date on the label

tecniche

HPLC: suitable
NMR: suitable
gas chromatography (GC): suitable

Punto di fusione

71-73 °C

Compatibilità

passes test for identity (NMR)

applicazioni

agriculture
environmental

Formato

neat

Temperatura di conservazione

2-8°C

Stringa SMILE

COP(=S)(Oc1cc(Cl)c(Br)cc1Cl)c2ccccc2

InChI

1S/C13H10BrCl2O2PS/c1-17-19(20,9-5-3-2-4-6-9)18-13-8-11(15)10(14)7-12(13)16/h2-8H,1H3
CVRALZAYCYJELZ-UHFFFAOYSA-N

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Descrizione generale

Leptophos, an organophosphorus insecticide found to be persistent in the environment, shows neurotoxic effects in humans. Its mode of action for pest control involves the inhibition of acetylcholinesterase enzyme activity.

Applicazioni

Leptophos may be used as an analytical reference standard for the quantification of the analyte in vegetables using solid phase micro-extraction coupled with gas chromatography-flame photometric detector (SPME-GC-FPD).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Note legali

PESTANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Avvertenze

Danger

Indicazioni di pericolo

H300,H311,H370,H410

Classi di pericolo

Acute Tox. 2 Oral - Acute Tox. 3 Dermal - Aquatic Acute 1 - Aquatic Chronic 1 - STOT SE 1

Codice della classe di stoccaggio

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe di pericolosità dell'acqua (WGK)

WGK 3

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificati d'analisi (COA)

Lot/Batch Number
BCCC5203
BCBZ7738
BCBW5130

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Determination of organophosphorus pesticide residues in vegetables using solid phase micro-extraction coupled with gas chromatography-flame photometric detector.
Sapahin AH, et al.
Arabian Journal of Chemistry, 23(1), 636-641 (2014)
Photodegradation of leptophos.
Riskallah RM, et al.
Bulletin of Environmental Contamination and Toxicology, 23(1), 636-641 (1979)
T Yamauchi et al.
The Journal of toxicological sciences, 14(1), 11-21 (1989-02-01)
The repeated intravenous injections (RIVInj) of 5 mg/kg/day leptophos [O-(4-bromo-2, 5-dichlorophenyl) O-methyl phenylphosphonothioate] for 3 consecutive days caused delayed ataxia in 4 out of 9 hens (44.4%). And one out of 9 hens (11.1%) given RIVInj of 3 mg/kg leptophos
M Farage-Elawar et al.
Journal of toxicology and environmental health, 21(4), 455-469 (1987-01-01)
The effects of desbromoleptophos, fenitrothion, and fenthion on brain acetylcholinesterase (AChE), brain neurotoxic esterase (NTE), and walking were investigated in immature chicks, below the age of organophosphorus ester-induced delayed neurotoxicity (OPIDN). Seventy-five milligrams per kilogram of the delayed neurotoxicant desbromoleptophos
Y Tian et al.
The Tohoku journal of experimental medicine, 185(3), 161-171 (1998-11-21)
Delayed neuropathy and inhibition of soluble neuropathy target esterase (NTE) and acetylcholinesterase (AChE) activities in different regions of brain and spinal cord of adult hens were studied after the intravenous administration of leptophos (30 mg/kg), tri-o-cresyl phosphate (TOCP 40 mg/kg)
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Protocolli

US EPA Method 8141: GC Analysis of Organophosphorus Pesticides (OP-Pest) on Equity®-5, NPD Detection

analytical standard; Tokuthion, technical grade, pkg of 50 mg; Crotoxyphos; Phorate; Azinphos-ethyl; Diazinon; Azinphos-methyl; Demeton-O; Dimethoate; Chlorpyrifos-methyl

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