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19-4497

Metronidazole

Name: Metronidazole
Brand: SAJ

SAJ first grade, ≥99.0%

Sinonimo/i:

2-Methyl-5-nitroimidazole-1-ethanol

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About This Item

Formula empirica (notazione di Hill):

C₆H₉N₃O₃

Numero CAS:

443-48-1

Peso molecolare:

171.15

Beilstein:

611683

Numero CE:

207-136-1

Numero MDL:

MFCD00009750

Codice UNSPSC:

12352005

ID PubChem:

329751879

Grado

SAJ first grade

Saggio

≥99.0%

Forma fisica

solid

Disponibilità

available only in Japan

Punto di fusione

159-161 °C (lit.)

Spettro attività antibiotica

Gram-negative bacteria
parasites

Modalità d’azione

DNA synthesis | interferes

Stringa SMILE

CC1=NC=C([N+]([O-])=O)N1CCO

InChI

1S/C6H9N3O3/c1-5-7-4-6(9(11)12)8(5)2-3-10/h4,10H,2-3H2,1H3
VAOCPAMSLUNLGC-UHFFFAOYSA-N

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Descrizione generale

Chemical structure: imidazole

Pittogrammi

GHS08

Avvertenze

Danger

Indicazioni di pericolo

H340,H350,H373

Consigli di prudenza

P202 - P260 - P280 - P308 + P313 - P405 - P501

Classi di pericolo

Carc. 1B - Muta. 1B - STOT RE 2

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

Certificati d'analisi (COA)

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Efficacy of the antimicrobial peptide TP4 against Helicobacter pylori infection: in vitro membrane perturbation via micellization and in vivo suppression of host immune responses in a mouse model.

Jayaram Lakshmaiah Narayana et al.

Oncotarget, 6(15), 12936-12954 (2015-05-24)

Helicobacter pylori infection is marked by a strong association with various gastric diseases, including gastritis, ulcers, and gastric cancer. Antibiotic treatment regimens have low success rates due to the rapid occurrence of resistant H. pylori strains, necessitating the development of

Metronidazole is still the drug of choice for treatment of anaerobic infections.

Sonja Löfmark et al.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 50 Suppl 1, S16-S23 (2010-01-14)

Metronidazole has been used for the treatment of infections for >45 years and is still successfully used for the treatment of trichomoniasis, amoebiasis, and giardiasis. Anaerobic bacterial infections caused by Bacteroides species, fusobacteria, and clostridia respond favorably to metronidazole therapy.

Treatment failure and recurrence of Clostridium difficile infection following treatment with vancomycin or metronidazole: a systematic review of the evidence.

Konstantinos Z Vardakas et al.

International journal of antimicrobial agents, 40(1), 1-8 (2012-03-09)

The objective of this review was to evaluate the frequency of treatment failure and recurrence of Clostridium difficile infection (CDI) following treatment with vancomycin or metronidazole in recently performed studies (last 10 years). Searches in PubMed and Scopus were performed

Antibiotic prophylaxis for hysterectomy, a prospective cohort study: cefuroxime, metronidazole, or both?

T H I Brummer et al.

BJOG : an international journal of obstetrics and gynaecology, 120(10), 1269-1276 (2013-06-22)

To evaluate cefuroxime and metronidazole antibiotic prophylaxis. Observational nonrandomised 1-year prospective cohort study. Fifty-three hospitals in Finland. A total of 5279 women undergoing hysterectomy for benign indications, with cefuroxime given to 4301 and metronidazole given to 2855. Excluding other antibiotics

Guidelines for diagnosis, treatment, and prevention of Clostridium difficile infections.

Christina M Surawicz et al.

The American journal of gastroenterology, 108(4), 478-498 (2013-02-27)

Clostridium difficile infection (CDI) is a leading cause of hospital-associated gastrointestinal illness and places a high burden on our health-care system. Patients with CDI typically have extended lengths-of-stay in hospitals, and CDI is a frequent cause of large hospital outbreaks

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