SCT247

BioTracker MultiTASQ G-Quadruplex (G4) Cell Probe

• Sinonimo/i: G quadruplex probe, G4 ligand, G4 probe, G4 tetrad probe, Live Cell Imaging Probe, click chemistry probe
• Codice UNSPSC: 41106514
• NACRES: NA.52

Proprietà

• Confezionamento: vial of 1 mg
• Livello qualitativo: 100
• Produttore/marchio commerciale: Millipore
• Modalità di accrescimento: N/A
• tecniche: DNA sequencing: suitable; RNA extraction: suitable; nucleic acid detection: suitable
• Metodo di rivelazione: fluorometric
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C

Descrizione

Applicazioni

DNA/RNA G-quadruplexes (G4s) are four-stranded nucleic acid structures that fold from numerous guanine (G)-rich sequences found in the genome and transcriptome. Their abundance and localization in critical regulatory regions make them key players in genetic diseases (cancer, neuropathology), but not only (e.g., viral infection). For this reason G4s have garnered intense interest as potential targets in different therapeutic areas
The BioTracker^™ MultiTASQ G-quadruplex G4 cell probe is optimized for detection (1) and/or the isolation of G4s (2,3). MultiTASQ utilizes the template-assembled synthetic G-quartets (TASQ) (4) concept as a biomimetic ligand for G-quadruplexes, a design which results in high specificity for folded G4.
References
1. Nat. Chem. 2021, 13(7): 626-633
2. ACS Chem Biol. 2021, 16(5): 905-914

Purity: > 98% confirmed by HPLC, HNMR, LC-MS and elemental analysis.

Caratteristiche e vantaggi

MultiTASQ detects ribosomal RNA-G4 associated with perinuclear rough ER regions to a greater degree compared to BG4 antibody. MultiTASQ is an alkynylated probe that allows for background-free detection via click chemistry and is suitable for G4 capture chemi-precipitation and click imaging applications. MultiTASQ is compatible with live-cell incubation. The BioTracker MultiTASQ G4 cell probe is a uniquely designed, versatile tool for G4 detection and analysis.

Stato fisico

Lyophilized. White solid.

Stoccaggio e stabilità

Store BioTracker BioCyTASQ G-quadruplex G4 cell probe at -20°C, desiccated and protected from light

Altre note

Fluorescent detection of nucleic acid G4 quadruplexes in cells and tissues using click chemistry

Note legali

BioTracker is a trademark of Merck KGaA, Darmstadt, Germany

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable