MABN323

Anti-Ermin Antibody, clone 160

clone 160, from mouse

• Sinonimo/i: Ermin, Juxtanodin
• Codice UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Proprietà

• Origine biologica: mouse
• Livello qualitativo: 100
• Forma dell’anticorpo: purified immunoglobulin
• Tipo di anticorpo: primary antibodies
• Clone: 160, monoclonal
• Reattività contro le specie: mouse, rat
• tecniche: immunocytochemistry: suitable; immunohistochemistry: suitable; western blot: suitable
• Isotipo: IgG2aκ
• N° accesso NCBI: NP_084248
• N° accesso UniProt: Q5EBJ4
• Condizioni di spedizione: wet ice
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: mouse ... Ermn(77767)

Descrizione

Descrizione generale

Ermin is also known as Juxtanodin (JN). Ermin is involved in cytoskeletal rearrangements during myelinogenesis and in the maintenance and stability of the myelin sheath in adults. Ermin is also thought to be important in oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the plasticity of related structures in the mature CNS. Ermin is exclusively expressed by oligodendrocytes in the brain and spinal cord, where it appears in the late stages of myelination, and in the mature nerves, it is localized in the outer cytoplasmic lip of the myelin sheath and the paranodal loops.

Immunogeno

Recombinant protein corresponding to mouse Ermin.

Applicazioni

Anti-Ermin Antibody, clone 160 is a highly specific mouse monoclonal antibody, that targets Ermin & has been tested in western blotting, ICC & IHC.

Immunohistochemistry Analysis: A representative lot from an independent laboratory detected Ermin in mouse wild type sagittal brain sections, and demonstrated a loss of signal in mouse OL-ablated sagittal brain sections (Brockschnieder, D., et al. (2006). J Neurosci. 26(3):737-762).

Immunocytochemistry Analysis: A representative lot from an independent laboratory detected Ermin in certain mouse brain and optic nerve sections (Brockschnieder, D., et al. (2006). J Neurosci. 26(3):737-762).

Research Category
Neuroscience

Research Sub Category
Developmental Neuroscience

Qualità

Evaluated by Western Blotting in mouse brain tissue lysate.

Western Blotting Analysis: 1 µg/mL of this antibody detected Ermin in 10 µg of mouse brain tissue lysate.

Descrizione del bersaglio

~42 kDa observed. The calculated molecular weight of this protein is 32 kDa; however, it has been observed at ~42 kDa (Brockschnieder, D., et al. (2006). J Neurosci. 26(3):737-76.).

Stato fisico

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stoccaggio e stabilità

Stable for 1 year at 2-8°C from date of receipt.

Risultati analitici

Control
Mouse brain tissue lysate

Altre note

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable