MABE415
Anti-FoxP2 Antibody, clone FOXP2-73A/8
clone FOXP2-73A/8, from mouse
Sinonimo/i:
Forkhead box protein P2, CAG repeat protein 44, Trinucleotide repeat-containing gene 10 protein
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About This Item
Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Prodotti consigliati
Origine biologica
mouse
Livello qualitativo
Forma dell’anticorpo
purified immunoglobulin
Tipo di anticorpo
primary antibodies
Clone
FOXP2-73A/8, monoclonal
Reattività contro le specie
human
tecniche
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
Isotipo
IgG1κ
N° accesso NCBI
N° accesso UniProt
Condizioni di spedizione
wet ice
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... FOXP2(93986)
Descrizione generale
Forkhead box protein P2 (FoxP2) is a multidomain transcriptional repressor that belongs to the Fox family of proteins. The FoxP2 protein contains a forkhead-box DNA-binding domain, characteristic of the FOX group of transcription factors. In addition, this protein contains a polyglutamine tract, as well as zinc finger and leucine zipper motifs. In order for FoxP2 to bind DNA, it forms homodimers and heterodimers with FoxP1 and FoxP4. The forkhead box family of proteins play an important role in immune response, organ development and the development of cancer. Functional studies in vertebrates suggest this gene plays a role in the modulation of neural plasticity. In line with these findings, mutations of FoxP2 in humans have been linked to speech and language disorders.
Specificità
This antibody recognizes FoxP2 isoforms at 70 kDa, 48 kDa, and 40 kDa.
Immunogeno
GST-tagged recombinant protein corresponding to the N-terminus of Human FoxP2.
Applicazioni
Detect FOXP2 using this mouse monoclonal antibody, Anti-FoxP2 Antibody, clone FOXP2-73A/8 validated for use in western blotting & IHC.
Western Blotting Analysis: 1 µg/mL from a representative lot detected FoxP2 in 10 µg of THP-1 cell lysate.
Immunoprecipitation Analysis (IP): A representative lot of this antibody was demonstrated to immunoprecipitate FoxP2 using growth arrested 143B cells (Gascoyne D.M., et al. (2015). PLoS One, 10(6):e0128513).
Immunohistochemistry Analysis: A representative lot from an independent laboratory detected FoxP2 in human tonsil tissues (Campbell, A. J., et al. (2010). Br J Haematol. 149(2):221-230.).
Immunohistochemistry Analysis: A representative lot from an independent laboratory detected FoxP2 in proliferating chondrocytes of murine E17.5 long bone (Gascoyne D.M., et al. (2015). PLoS One, 10(6):e0128513).
Immunoprecipitation Analysis (IP): A representative lot of this antibody was demonstrated to immunoprecipitate FoxP2 using growth arrested 143B cells (Gascoyne D.M., et al. (2015). PLoS One, 10(6):e0128513).
Immunohistochemistry Analysis: A representative lot from an independent laboratory detected FoxP2 in human tonsil tissues (Campbell, A. J., et al. (2010). Br J Haematol. 149(2):221-230.).
Immunohistochemistry Analysis: A representative lot from an independent laboratory detected FoxP2 in proliferating chondrocytes of murine E17.5 long bone (Gascoyne D.M., et al. (2015). PLoS One, 10(6):e0128513).
Qualità
Evaluated by Western Blotting in HeLa cell lysate.
Western Blotting Analysis: 1 µg/mL of this antibody detected FoxP2 in 10 µg of HeLa cell lysate.
Western Blotting Analysis: 1 µg/mL of this antibody detected FoxP2 in 10 µg of HeLa cell lysate.
Descrizione del bersaglio
~80 kDa observed. Uniprot describes 9 isoforms between 9-83 kDa
Stato fisico
Format: Purified
Altre note
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
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Codice della classe di stoccaggio
12 - Non Combustible Liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Aberrant expression of the neuronal transcription factor FOXP2 in neoplastic plasma cells.
Campbell, Andrew J, et al.
British Journal of Haematology, 149, 221-230 (2010)
Pedro M Rodenas-Cuadrado et al.
The Journal of comparative neurology, 526(8), 1235-1266 (2018-01-04)
Genes including FOXP2, FOXP1, and CNTNAP2, have been implicated in human speech and language phenotypes, pointing to a role in the development of normal language-related circuitry in the brain. Although speech and language are unique to humans a comparative approach
Takako Kita et al.
The European journal of neuroscience, 44(11), 2899-2908 (2016-10-08)
Projections from the posterior intralaminar thalamic nuclei and the superior colliculus (SC) to the subthalamic nucleus (STN) and the zona incerta (ZI) have been described in the primate and rodent. The aims of this study was to investigate several questions
Boglárka Barsy et al.
Nature neuroscience, 23(5), 625-637 (2020-04-15)
Decades of research support the idea that associations between a conditioned stimulus (CS) and an unconditioned stimulus (US) are encoded in the lateral amygdala (LA) during fear learning. However, direct proof for the sources of CS and US information is
Zachary A Abecassis et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(4), 743-768 (2019-12-08)
Within the basal ganglia circuit, the external globus pallidus (GPe) is critically involved in motor control. Aside from Foxp2+ neurons and ChAT+ neurons that have been established as unique neuron types, there is little consensus on the classification of GPe
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