MAB5328
Anti-RAGE Antibody, clone DD/A11 or A11
Chemicon®, from mouse
Sinonimo/i:
Receptor for Advanced Glycosylation End Products.
Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
About This Item
Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Prodotti consigliati
Origine biologica
mouse
Livello qualitativo
Forma dell’anticorpo
purified antibody
Tipo di anticorpo
primary antibodies
Clone
DD/A11, monoclonal
mAbA11, monoclonal
Reattività contro le specie
human, bovine, mouse
Reattività contro le specie (prevista in base all’omologia)
rat
Produttore/marchio commerciale
Chemicon®
tecniche
ELISA: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
Isotipo
IgG2a
N° accesso NCBI
N° accesso UniProt
Condizioni di spedizione
wet ice
modifica post-traduzionali bersaglio
glycosylation
Informazioni sul gene
human ... AGER(177)
Descrizione generale
RAGE (Receptor for Advanced Glycosylation End Products) is a 35 kDa cell surface receptor that binds molecules modified by advanced glycation end products (AGEs), an irreversible non-enzymatic reaction occuring from the interaction of proteins and lipids with glucose. The increased expression of RAGE is associated with many disorders, such as diabetic vasculopathy, neuropathy, retinopathy and neuropathy, Alzheimer’s disease and immune/inflammatory reactions of the vessel walls. AGE/RAGE accumulates at sites of vascular disease in diabetes, but blockade of RAGE suppresses development of atherosclerosis and vascular disorders. RAGE binds to amyloid beta, which is overproduced in neurons and vessels in Alzheimer′s disease, and this interaction results in oxidative stress leading to neuronal degeneration.
Specificità
RAGE (Receptor for Advanced Glycosylated End Products). The antibody recognizes both natural and recombinant RAGE.
Immunogeno
Recombinant truncated extracellular part of RAGE produced in E. coli.
Applicazioni
Anti-RAGE Antibody, clone DD/A11 or A11 is an antibody against RAGE for use in ELISA, IC, IH & WB.
Immunohistochemistry:
A previous lot of this antibody was shown to be reactive on paraffin embedded tissue sections.
Immunocytochemistry:
A previous lot was shown to work on cells fixed with ice cold acetone using a Cy3 conjugated secondary antibody.
ELISA:
A previous lot was shown to work on direct ELISA.
Immunoblotting:
Recognizes a band of ~48kDa in bovine lung extract.
Optimal working dilutions must be determined by end user.
A previous lot of this antibody was shown to be reactive on paraffin embedded tissue sections.
Immunocytochemistry:
A previous lot was shown to work on cells fixed with ice cold acetone using a Cy3 conjugated secondary antibody.
ELISA:
A previous lot was shown to work on direct ELISA.
Immunoblotting:
Recognizes a band of ~48kDa in bovine lung extract.
Optimal working dilutions must be determined by end user.
Qualità
Routinely evaluated by Western Blot on Mouse Brain lysates.
Western Blot:
1:500 dilution of this lot detected RAGE on 10 μg of Mouse Brain lysates.
Western Blot:
1:500 dilution of this lot detected RAGE on 10 μg of Mouse Brain lysates.
Descrizione del bersaglio
48 kDa
Stato fisico
Format: Purified
Purified mouse monoclonal IgG2a in buffer containing 0.02 M phosphate buffer, 0.25 M NaCl, and 0.1% sodium azide.
Risultati analitici
Control
Lung tissue, mouse brain lysate.
Lung tissue, mouse brain lysate.
Altre note
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Note legali
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Non trovi il prodotto giusto?
Prova il nostro Motore di ricerca dei prodotti.
Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 2
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.
Possiedi già questo prodotto?
I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Cardiovascular diabetology in the core of a novel interleukins classification: the bad, the good and the aloof.
Enrique Z Fisman, Michael Motro, Alexander Tenenbaum
Cardiovascular Diabetology null
Rosaria Bassi et al.
Journal of neuro-oncology, 87(1), 23-33 (2007-11-03)
HMGB1 (high mobility group box 1 protein) is a nuclear protein that can also act as an extracellular trigger of inflammation, proliferation and migration, mainly through RAGE (the receptor for advanced glycation end products); HMGB1-RAGE interactions have been found to
Anna Kamynina et al.
Journal of cellular physiology, 236(9), 6496-6506 (2021-02-12)
The receptor for advanced glycation end products (RAGE) is a signal receptor first shown to be activated by advanced glycation end products, but also by a variety of signal molecules, including pathological advanced oxidation protein products and β-amyloid. However, most
Autocrine S100B effects on astrocytes are mediated via RAGE.
Gerald Ponath, Christiane Schettler, Florian Kaestner, Bjorn Voigt, Dennis Wentker et al.
Journal of Neuroimmunology null
Alternatively spliced RAGEv1 inhibits tumorigenesis through suppression of JNK signaling.
Kalea, Anastasia Z, et al.
Cancer Research, 70, 5628-5638 (2010)
Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..
Contatta l'Assistenza Tecnica.