MAB390-100UG
Anti-p75 LNGFR Antibody, Saporin conjugated, clone 192
clone 192, Chemicon®, from mouse
Sinonimo/i:
p75 Low Affinity Neurotrophin Receptor, NGFR
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About This Item
Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Prodotti consigliati
Origine biologica
mouse
Livello qualitativo
Coniugato
saporin
Tipo di anticorpo
primary antibodies
Clone
192, monoclonal
Reattività contro le specie
rat
Non deve reagire con
mouse, human
Produttore/marchio commerciale
Chemicon®
tecniche
immunolesioning: suitable
Isotipo
IgG1
N° accesso NCBI
N° accesso UniProt
Condizioni di spedizione
dry ice
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... NGFR(4804)
Specificità
Rat NGF receptor. MAB365 is the monoclonal antibody used for MAB390-SAP
Applicazioni
Anti-p75 Low Affinity Nerve Growth Factor Receptor Antibody, Saporin conjugated, clone 192 is an antibody against p75 Low Affinity Nerve Growth Factor Receptor for use in 0.
Immunotoxin (see "Protocols" for Technical Notes)
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neurodegenerative Diseases
Neurochemistry & Neurotrophins
Neurodegenerative Diseases
Neurochemistry & Neurotrophins
Stato fisico
Saporin Conjugated. 192-IgG-SAP is sterile filtered and presented in Dulbecco′s PBS with no preservative.
Stoccaggio e stabilità
Centrifuge material at low speed in microfuge to ensure all of the solution is at the bottom of the tube. Vortex gently. Long term storage at -70ºC or below. Short term storage at -20ºC or 2-8ºC with appropriate antibacterial agent if compatible with the intended application. The sterile conjugate is stable at 2-8ºC for several months. Avoid repeated freezing and thawing. Glycerol (1:1) can be added for additional stability if compatible with the intended application. This immunotoxin may be handled safely using standard laboratory procedures as the cross-species reactivity between these anti-rat p75 antibodies and the human form of p75 is negligible.
Altre note
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Note legali
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Certificati d'analisi (COA)
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Selective immunolesions of hippocampal cholinergic input fail to impair spatial working memory.
McMahan, R W, et al.
Hippocampus, 7, 130-136 (1997)
M M Nicolle et al.
Neuroscience, 77(3), 649-659 (1997-04-01)
Lesion models in the rat were used to examine the effects of removing innervation of the hippocampal formation on glutamate receptor binding in that system. Bilateral aspiration of the entorhinal cortex was used to remove the cortical innervation of the
Toxin-induced death of neurotrophin-sensitive neurons.
R G Wiley
Methods in molecular biology (Clifton, N.J.), 169, 217-222 (2001-01-06)
Complete and selective cholinergic denervation of rat neocortex and hippocampus but not amygdala by an immunotoxin against the p75 NGF receptor.
Heckers, S, et al.
The Journal of Neuroscience, 14, 1271-1289 (1994)
J J Waite et al.
Neuroscience, 65(2), 463-476 (1995-03-01)
Immunolesions of the cholinergic basal forebrain were produced in rats using various intraventricular doses of the immunotoxin 192 immunoglobulin G-saporin: 0.34, 1.34, 2.0, 2.7 and 4.0 micrograms/rat. A battery of behavioral tests, chosen on the basis of reported sensitivity to
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