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Key Documents

MAB341

Sigma-Aldrich

Anti-GABA A Receptor β 2,3 Chain Antibody, clone BD17

clone BD17, Chemicon®, from mouse

Sinonimo/i:

GABA(A) receptor subunit beta-2, gamma-aminobutyric acid (GABA) A receptor, beta 2, gamma-aminobutyric acid A receptor, beta 2

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About This Item

Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Origine biologica

mouse

Livello qualitativo

100

Forma dell’anticorpo

purified immunoglobulin

Tipo di anticorpo

primary antibodies

Clone

BD17, monoclonal

Reattività contro le specie

mouse, feline, monkey, bovine

Reattività contro le specie (prevista in base all’omologia)

rat, human

Produttore/marchio commerciale

Chemicon®

tecniche

immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

Isotipo

IgG1

N° accesso NCBI

NM_000813.2

N° accesso UniProt

P47870

Condizioni di spedizione

dry ice

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... GABRB2(2561)

Descrizione generale

Gamma-aminobutyric acid type A (GABAA) receptors are members of the neurotransmitter ligand-gated ion channels that mediate neuronal inhibition on binding GABA. The effects of GABA on GABAA receptors are modulated by a range of therapeutically important drugs, including barbiturates, anaesthetics and benzodiazepines.

Specificità

Reacts with the β-chain of the GABAA receptor.

Immunogeno

Epitope: Extracellular domain of the beta2 & beta3 subunits of the GABAA receptor
Purified GABA/benzodiazepine receptor from bovine cortex

Applicazioni

Detect GABA A Receptor β 2 using this Anti-GABA A Receptor β 2, 3 Chain Antibody, clone BD17 validated for use in IH, IP & WB.
Immunohistochemistry:
A 10-20 μg/mL concetration of a previous lot was used in IH.

Immunoprecipitation:
A previous lot of this antibody was used in IP.

Western blot:
5-20 µg/mL. Recognizes a 55 kDa band corresponding to the beta chain of the GABAA receptor.

Optimal working dilutions must be determined by end user.

Qualità

Evaluated by Western Blot on mouse brain membrane lysates.

Western Blot:
1:500 dilution of this antibody detected GABA A Receptor β 2,3 Chain on 10 μg of mouse brain membrane lysates.

Descrizione del bersaglio

55 kDa

Linkage

Replaces: AB5952

Stato fisico

Format: Purified
Purified mouse monoclonal IgG1 liquid in buffer containing 10 mM potassium phosphate buffer pH 7.4 with 150 mM NaCl

Altre note

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Note legali

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Activity deprivation reduces miniature IPSC amplitude by decreasing the number of postsynaptic GABA(A) receptors clustered at neocortical synapses.
Valerie Kilman, Mark C W van Rossum, Gina G Turrigiano
The Journal of Neuroscience null
Positive feedback regulation between gamma-aminobutyric acid type A (GABA(A)) receptor signaling and brain-derived neurotrophic factor (BDNF) release in developing neurons.
Porcher, C; Hatchett, C; Longbottom, RE; McAinch, K; Sihra, TS; Moss, SJ; Thomson, AM; Jovanovic, JN
The Journal of Biological Chemistry null
Human ?1?3?2L gamma-aminobutyric acid type A receptors: High-level production and purification in a functional state.
Dostalova, Z; Zhou, X; Liu, A; Zhang, X; Zhang, Y; Desai, R; Forman, SA; Miller, KW
Protein Science null
Developmentally regulated changes in cellular compartmentation and synaptic distribution of actin in hippocampal neurons.
Wandong Zhang, Deanna L Benson, Wandong Zhang, Deanna L Benson
Journal of Neuroscience Research null
Gamma-aminobutyric acid (GABA) is an autocrine excitatory transmitter in human pancreatic beta-cells.
Braun, M; Ramracheya, R; Bengtsson, M; Clark, A; Walker, JN; Johnson, PR; Rorsman, P
Diabetes null
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