ABS528
Anti-S1P lyase Antibody
from rabbit, purified by affinity chromatography
Sinonimo/i:
S1PL, SPL1, mSPL, Sphingosine-1-phosphate aldolase
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About This Item
Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Prodotti consigliati
Origine biologica
rabbit
Livello qualitativo
Forma dell’anticorpo
affinity isolated antibody
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Purificato mediante
affinity chromatography
Reattività contro le specie
mouse
tecniche
western blot: suitable
N° accesso NCBI
N° accesso UniProt
Condizioni di spedizione
wet ice
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
mouse ... Sgpl1(20397)
Descrizione generale
S1P lyase is an important enzyme in lipid, steroid, and ceramide metabolism. S1P lyase 1 specifically cleaves phosphorylated sphingoid bases such as sphingosine-1-phosphate into fatty aldehydes and phosphoethanolamine. S1P lyase also plays roles in apoptosis with regards to regulation of ceramide production and plays roles in cell differentiation via its role in androgen and estrogen metabolism as well as that of other important lipids and bioactive lipid derivatives. S1P lyase is expressed in the endoplasmic reticulum in many cells. Interestingly, because Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that promotes cardiomyocyte survival and contributes to ischemic preconditioning, its catabolism by S1P lyase is very important in recovery from heart attacks or other ischemia related events, and thus S1P lyase is being examined as a potential new therapeutic target for reperfusion therapy in heart disease.
Immunogeno
Epitope: cytoplasmic domain
Linear peptide corresponding to the cytoplasmic domain of Mouse S1P lyase.
Applicazioni
Research Category
Signaling
Metabolism
Signaling
Metabolism
Research Sub Category
Lipid Metabolism & Weight Regulation
Lipid Signaling
Lipid Metabolism & Weight Regulation
Lipid Signaling
This Anti-S1P lyase Antibody is validated for use in Western Blotting for the detection of S1P lyase.
Western Blotting Analysis: A representative lot of this antibody detected S1P lyase in 30 μg of lysate from various mice tissues (Bektas, M., et al. (2010). Journal of Biological Chemistry Vol. 285, NO. 14, pp. 10880–10889)
Qualità
Evaluated by Western Blotting in mouse lung tissue lysate.
Western Blotting Analysis: 1 μg/mL of this antibody detected SP-lyase1 in 10 µg of mouse lung tissue lysate.
Western Blotting Analysis: 1 μg/mL of this antibody detected SP-lyase1 in 10 µg of mouse lung tissue lysate.
Descrizione del bersaglio
~ 56 kDa observed
Stato fisico
Antigen Affinity Purified
Purified rabbit polyclonal in buffer with 0.05% sodium azide.
Stoccaggio e stabilità
Stable for 1 year at 2-8°C from date of receipt.
Altre note
Concentration: Please refer to lot specific datasheet.
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 2
Certificati d'analisi (COA)
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Younghun Jung et al.
Brain research, 1799, 148171-148171 (2022-11-22)
Sphingolipid-1-phosphate (S1P) signaling through the activation S1P receptors (S1PRs) plays critical roles in cellular events in the brain. Aberrant S1P metabolism has been identified in the brains of Alzheimer's disease (AD) patients. Our recent studies have shown that treatment with
Sphingosine 1-phosphate lyase deficiency disrupts lipid homeostasis in liver.
Bektas, M; Allende, ML; Lee, BG; Chen, W; Amar, MJ; Remaley, AT; Saba, JD; Proia, RL
The Journal of Biological Chemistry null
Yuko Kageyama et al.
Bioscience reports, 40(7) (2020-07-03)
Liver regeneration is an extremely complicated process that is regulated by a number of signaling pathways. Sphingosine 1-phosphate (S1P), a potent bioactive lipid mediator playing crucial roles in various cellular responses through its receptors, has been attracting attention in the
Baasanjav Uranbileg et al.
Clinical and translational medicine, 12(9), e1056-e1056 (2022-09-21)
In addition to potent agonist properties for sphingosine 1-phosphate (S1P) receptors, intracellularly, S1P is an intermediate in metabolic conversion pathway from sphingolipids to glycerolysophospholipids (glyceroLPLs). We hypothesized that this S1P metabolism and its products might possess some novel roles in
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