ABS502
Anti-LTBP-1 Antibody
serum, from rabbit
Sinonimo/i:
Latent-transforming growth factor beta-binding protein 1, LTBP-1, Transforming growth factor beta-1-binding protein 1, TGF-beta1-BP-1
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About This Item
Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Prodotti consigliati
Origine biologica
rabbit
Livello qualitativo
Forma dell’anticorpo
serum
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Reattività contro le specie
human, rat
tecniche
immunocytochemistry: suitable
western blot: suitable
N° accesso NCBI
N° accesso UniProt
Condizioni di spedizione
dry ice
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... LTBP1(4052)
Descrizione generale
Latent-transforming growth factor beta-binding protein 1 (LTBP-1) is also called Transforming growth factor beta-1-binding protein 1 (TGF-beta1-BP-1). A large latent complex of TGFB1 from platelets is composed of the TGFB1 molecule non-covalently associated with a disulfide-bonded complex of a dimer of the N-terminal propeptide of the TGFB1 precursor and LTBP1. LTBP1 does not bind directly to active TGFB1 only to proforms. LTBP1 appears to be involved in the secretion of TGFB1 to sites at which it is stored or activated, and it is critical in controlling the action of TGFB1. LTBP1 may also play a role in extracellular matrix building and calcium binding mediated signaling surrounding TGFB1 activated signaling pathways. Also, because of its critical role in TGFB1 metabolism, LTBP1 is an important player in many developmental processes including embryo implantation and growth. LTBP1 is also a player in at least two distinct breast cancer metastasis signatures and has both a long and short isoform that work to establish and maintain the spatial restriction of TGFbeta bioavailability during development of many tissues including mammary development.
Immunogeno
His-tagged recombinant protein corresponding to human LTBP-1.
Applicazioni
Immunocytochemistry Analysis: A representative lot detected LTBP-1 in transfected HEK293 cells (Chen, Q., et al. (2007). JBC. 282(36):26418-26430).
Immunocytochemistry Analysis: A representative lot detected LTBP-1 in rat FRC cells (Chen, Q., et al. (2007). JBC. 282(36):26418-26430).
Immunocytochemistry Analysis: A representative lot detected LTBP-1 in rat FRC cells (Chen, Q., et al. (2007). JBC. 282(36):26418-26430).
Research Category
Signaling
Signaling
Research Sub Category
Signaling Neuroscience
Signaling Neuroscience
This Anti-LTBP-1 Antibody is validated for use in Western Blotting and Immunocytochemistry for the detection of LTBP-1.
Qualità
Evaluated by Western Blotting in human lung tissue lysate using a non-reduced gel.
Western Blotting Analysis: A 1:1,000 dilution of this antibody detected LTBP-1 in 10 µg of human lung tissue lysate using a non-reduced gel.
Western Blotting Analysis: A 1:1,000 dilution of this antibody detected LTBP-1 in 10 µg of human lung tissue lysate using a non-reduced gel.
Descrizione del bersaglio
~220 kDa observed. Uncharacterized band(s) may appear in some lysates.
Stato fisico
Rabbit polyclonal serum with 0.05% sodium azide.
Unpurified
Stoccaggio e stabilità
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Altre note
Concentration: Please refer to lot specific datasheet.
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Certificati d'analisi (COA)
Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Qian Chen et al.
The Journal of biological chemistry, 282(36), 26418-26430 (2007-06-21)
Latent transforming growth factor-beta-binding proteins (LTBPs) are extracellular matrix (ECM) glycoproteins that play a major role in storage of latent TGF-beta in the ECM and regulate its availability. We have previously identified fibronectin as a key molecule for incorporation of
Anupama Chandramouli et al.
Breast cancer research : BCR, 15(6), R111-R111 (2013-11-23)
Latent TGFβ binding proteins (LTBPs) govern TGFβ presentation and activation and are important for elastogenesis. Although TGFβ is well-known as a tumor suppressor and metastasis promoter, and LTBP1 is elevated in two distinct breast cancer metastasis signatures, LTBPs have not
Vineet Kumar Maurya et al.
Biology of reproduction, 89(4), 84-84 (2013-08-09)
Transforming growth factor-beta (TGF-B) plays an important role in embryo implantation; however, TGF-B requires liberation from its inactive latent forms (i.e., large latent TGF-B complex [LLC] and small latent TGF-B complex [SLC]) to its biologically active (i.e., monomer or dimer)
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