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ABN1370

Sigma-Aldrich

Anti-MTNR1B

from rabbit, purified by affinity chromatography

Sinonimo/i:

Mel-1B-R, Mel1b receptor, MT2

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About This Item

Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Clone:
polyclonal
application:
IHC
WB
Reattività contro le specie:
human
tecniche:
immunohistochemistry: suitable (paraffin)
western blot: suitable
citations:

Origine biologica

rabbit

Livello qualitativo

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Purificato mediante

affinity chromatography

Reattività contro le specie

human

tecniche

immunohistochemistry: suitable (paraffin)
western blot: suitable

N° accesso NCBI

N° accesso UniProt

Condizioni di spedizione

ambient

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... MTNR1B(4544)

Descrizione generale

Melatonin receptor type 1B (UniProt: P49286; also known as Mel-1B-R; Mel1b receptor) is encoded by the gene MTNR1B gene (Gene ID 4544) in human. Mel-1B-R is a high affinity receptor for melatonin that belongs to the G-protein coupled receptor 1 family. Mel-1B mediates the reproductive and circadian actions of melatonin. Melatonin is shown to be involved in body mass regulation in mammals and this effect is suggest to be mediated by a direct action of melatonin on Mel-1B receptors on brown adipocytes. Melatonin also acts as a chemopreventive agent and its levels inversely correlate with the risk of developing cancer. In this regard melatonin induces p38-dependent phosphorylation of both p53 and histone H2AX. Activation of the p53-dependent DNA damage response by melatonin is mediated by both Mel-1A and Mel-1B receptors. The absence of either receptor impairs melatonin′s ability to reduce both cell proliferation and clonogenic potential of cancer cells. (Brydon, L. et al. (2001). Endocrinology. 142(10):4264-4271; Santoro, R., et al. (2013). Carcinogenesis. 34(5):1051-1061).

Specificità

This polyclonal antibody detects melatonin receptor type 1B in human hippocampus membrane.

Immunogeno

A KLH-conjugated linear peptide corresponding to 16 amino acids from the C-terminal end of human melatonin receptor type 1B.

Applicazioni

Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected MTNR1B in human retina and human melanoma tissue.


Research Category
Stem Cell Research
This rabbit polyclonal Anti-MTNR1B, Cat. No. ABN1370 is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of Melatonin receptor type 1B.

Qualità

Evaluated by Western Blotting in human hippocampus membrane.

Western Blotting Analysis: 2 mg/mL of this antibody detected MTNR1B in 10 mg of human hippocampus membrane.


Descrizione del bersaglio

~38 kDa observed; 40.19 kDa calculated. Uncharacterized bands may be observed in some lysate(s).

Stato fisico

Affinity Purified
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stoccaggio e stabilità

Stable for 1 year at 2-8°C from date of receipt.

Altre note

Concentration: Please refer to lot specific datasheet.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1


Certificati d'analisi (COA)

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