ABC926

Anti-TRIM11 Antibody

from rabbit, purified by affinity chromatography

• Sinonimo/i: E3 ubiquitin-protein ligase TRIM11, Protein BIA1, RING finger protein 92, Tripartite motif-containing protein 11, TRIM11
• Codice UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Livello qualitativo: 100
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Purificato mediante: affinity chromatography
• Reattività contro le specie: mouse, human
• Reattività contro le specie (prevista in base all’omologia): canine (based on 100% sequence homology), rhesus macaque (based on 100% sequence homology)
• tecniche: immunohistochemistry: suitable (paraffin); western blot: suitable
• N° accesso NCBI: NP_660215
• N° accesso UniProt: Q96F44
• Condizioni di spedizione: wet ice
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... TRIM11(81559) ; mouse ... Trim11(94091)

Descrizione

Descrizione generale

E3 ubiquitin-protein ligase TRIM11 (UniProt Q96F44; also known as Protein BIA1, RING finger protein 92, Tripartite motif-containing 11, Tripartite motif-containing protein 11) is encoded by the TRIM11 (also known as BIA1, RNF92) gene (Gene ID 81559) in human. TRIM11 belongs to a family of more than 70 TRIM/RBCC proteins characterized by their shared tripartite motif structure, also known as the RBCC (RING finger, B-box, and coiled-coil) domain. The B-box and coiled coil regions are believed to participate in protein-protein interactions and formation of macromolecular complexes. TRIM proteins are involved in diverse cellular processes, including cell proliferation, differentiation, oncogenesis, and apoptosis. The presence of a RING domain suggests that TRIM proteins function as E3 ubiquitin ligases. The neuroprotective peptide humanin, activator-recruited cofactor (ARC) 105-kDa component (ARC105), the transcription factors Pax6 and PHOX2B are all known subrates targeted by TRIM11-mediated degradation through the ubiquitin-proteasome system. In addition, TRIM11 is also reported to interfere with the early steps of HIV-1 replication in host cells in a RING domain-dependent manner.

Specificità

This antibody is expected to react with all three spliced isoforms of human TRIM11.

Immunogeno

KLH-conjugated linear peptide corresponding to human TRIM11.

Applicazioni

Detect TRIM11 using this rabbit polyclonal Anti-TRIM11 Antibody, Cat. No. ABC926, validated for use in Western Blotting and Immunohistochemistry (Paraffin).

Immunohistochemistry Analysis: A 1:50-250 dilution from a representative lot detected TRIM11 in human prostate cancer, human colon cancer, human melanoma, and human kidney tissue.

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

Qualità

Evaluated by Western Blotting in murine macrophage RAW264.7 cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected TRIM11 in 10 µg of murine macrophage RAW264.7 cell lysate.

Descrizione del bersaglio

~53 kDa observed. 52.8 kDa (isoform 1), 43.0 kDa (isoform 2), and 52.6 kDa (isoform 3) calculated.

Stato fisico

Affinity purified

Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stoccaggio e stabilità

Stable for 1 year at 2-8°C from date of receipt.

Altre note

Concentration: Please refer to lot specific datasheet.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable