ABC482

Anti-ADE2 Antibody/SAICAR synthetase

from rabbit, purified by affinity chromatography

• Sinonimo/i: Multifunctional protein ADE2, Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase, Phosphoribosylaminoimidazole carboxylase, AIR carboxylase, AIRC
• Codice UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Livello qualitativo: 100
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Purificato mediante: affinity chromatography
• Reattività contro le specie: human
• Reattività contro le specie (prevista in base all’omologia): canine (based on 100% sequence homology), rat (based on 100% sequence homology), mouse (based on 100% sequence homology), rhesus monkey (based on 100% sequence homology), porcine (based on 100% sequence homology), chimpanzee (based on 100% sequence homology), bovine (based on 100% sequence homology), feline (based on 100% sequence homology)
• tecniche: western blot: suitable
• N° accesso NCBI: NP_001072992
• N° accesso UniProt: P22234
• Condizioni di spedizione: wet ice
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... PAICS(10606)

Descrizione

Descrizione generale

Multifunctional protein ADE2, which is encoded by the gene name PAICS, ADE2, AIRC, PAIS, is a member of the SAICAR synthetase family and the AIR carboxylase family. Multifunctional protein ADE2 includes the following two domains: Phosphoribosylaminoimidazole-succinocarboxamide synthase (SAICAR synthetase), and Phosphoribosylaminoimidazole carboxylase (AIR carboxylase/ AIRC). ADE2 is a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. ADE2 is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for ADE2. ADE2/ PAICS (phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase) is a protein-coding gene. Diseases associated with ADE2 include androgen insensitivity syndrome, and pseudohermaphroditism, and among its related super-pathways are Metabolic pathways and Purine metabolism.

Immunogeno

Epitope: SAICAR synthetase

KLH-conjugated linear peptide corresponding to human ADE2/SAICAR synthetase.

Applicazioni

This Anti-ADE2 antibody is validated for use in Western Blotting for the detection of ADE2.

Qualità

Evaluated by Western Blotting in TF-1, K562, HL-60, THP-1, Jurkat, and MOLT-4 cell lysate.

Western Blotting Analysis: 2.0 µg/mL of this antibody detected ADE2/SAICAR synthetase in 10 µg of TF-1, K562, HL-60, THP-1, Jurkat, and MOLT-4 cell lysate.

Descrizione del bersaglio

~47 kDa observed. Uncharacterized band(s) may appear in some lysates.

Altre note

Concentration: Please refer to lot specific datasheet.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable