ABC41-M

Anti-Mitofusin-1 Antibody

from rabbit, purified by affinity chromatography

• Sinonimo/i: Fzo homolog, Transmembrane GTPase MFN1, Mitofusion-1
• Codice UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Livello qualitativo: 100
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Purificato mediante: affinity chromatography
• Reattività contro le specie: human, rat, mouse
• tecniche: western blot: suitable
• N° accesso NCBI: NP_284941
• N° accesso UniProt: Q8IWA4
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... MFN1(55669)

Descrizione

Descrizione generale

Along with Mitofusin-2 (Mfn2), Mitofusin-1 (Mfn1) is a known protein mediator of mitochondrial fusion. Mitochondrial fusion regulates mitochondrial morphogensis and supports complementation between mitochondrial genomes in mammalian cells. Two Mfn1 transcripts are detected at similar levels in a variety of human tissues and are dramatically elevated in the heart. Human Mfn1 is known to be localized in the mitochondria. It is reported that point mutations in the conserved G1 and G2 region of the Mfn1 GTPase domain result in decreased formation and fragmentation of the mitochondria, respectively.

Specificità

This antibody recognizes Mitofusin-1 at the cytoplasmic domain.

Immunogeno

Epitope: Cytoplasmic Domain

KLH-conjugated linear peptide corresponding to the cytoplasmic domain of human Mitofusin-1.

Applicazioni

Detect Mitofusin-1 using this Anti-Mitofusin-1 Antibody validated for use in WB.

Research Category
Cell Structure

Research Sub Category
Organelle & Cell Markers

Qualità

Evaluated by Western Blot in HeLa cell lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected Mitofusin-1 in 10 µg HeLa cell lysate.

Descrizione del bersaglio

~86 kDa observed.
Three isoforms of Mitofusin-1 are produced by alternative splicing with molecular weights of ~42 kDa, ~71 kDa, and ~84 kDa Uncharacterized bands may appear at ~45 kDa, ~48 kDa, and ~55 kDa in some lysates.

Stato fisico

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stoccaggio e stabilità

Stable for 1 year at 2-8°C from date of receipt.

Risultati analitici

Control
HeLa cell lysate

Altre note

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable