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AB9690

Sigma-Aldrich

Anti-NMDAR2B phospho Tyrosine 1336 Antibody

Chemicon®, from rabbit

Sinonimo/i:

NR2B

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About This Item

Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Origine biologica

rabbit

Livello qualitativo

100

Forma dell’anticorpo

affinity purified immunoglobulin

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Purificato mediante

affinity chromatography

Reattività contro le specie

rat

Produttore/marchio commerciale

Chemicon®

tecniche

western blot: suitable

N° accesso NCBI

NM_000834.2

N° accesso UniProt

Q13224

Condizioni di spedizione

dry ice

modifica post-traduzionali bersaglio

phosphorylation (pTyr1336)

Informazioni sul gene

rat ... Grin2B(24410)

Specificità

NMDAR2B, phosphoTyrosine1336. The antibody recognizes a protein of ~180 kDa corresponding to NMDAR2B, phosphoTyrosine1336 in lysates from rat brain hippocampus. Immunolabeling is blocked by the phosphopeptide used as the immunogen but not the corresponding non-phosphopeptide. Immunolabeling is also blocked by l-phosphatase treatment.

Immunogeno

Synthetic peptide of amino acids surrounding the phosphoTyrosine 1336 site of rat NMDAR2B. The immunogen has 100% similarity with human and mouse.

Applicazioni

Detect NMDAR2B phospho Tyrosine 1336 using this Anti-NMDAR2B phospho Tyrosine 1336 Antibody validated for use in WB.
Research Category
Neuroscience
Research Sub Category
Neurotransmitters & Receptors
Western blot: 1:1,000.

Optimal working dilutions must be determined by the end user.

Linkage

Replaces: 07-533

Stato fisico

Affinity purified immunoglobulin. Liquid in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50% glycerol.

Stoccaggio e stabilità

Maintain at -20°C in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self defrosting freezer.

Note legali

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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NMDA-receptor trafficking and targeting: implications for synaptic transmission and plasticity.
Carroll, Reed C and Zukin, R Suzanne
Trends in Neurosciences, 25, 571-577 (2002)
D R Grosshans et al.
Nature neuroscience, 5(1), 27-33 (2001-12-12)
In the CA1 region of the rat hippocampus, long-term potentiation (LTP) requires the activation of NMDA receptors (NMDARs) and leads to an enhancement of AMPA receptor (AMPAR) function. In neonatal hippocampus, this increase in synaptic strength seems to be mediated
Jérémy Ferrier et al.
PloS one, 8(10), e77828-e77828 (2013-11-10)
Oxaliplatin is an anticancer drug used for the treatment of advanced colorectal cancer, but it can also cause painful peripheral neuropathies. The pathophysiology of these neuropathies has not been yet fully elucidated, but may involve spinal N-methyl-D-aspartate (NMDA) receptors, particularly

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