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Documenti fondamentali

AB5832

Sigma-Aldrich

Anti-BACE Antibody

Chemicon®, from rabbit

Sinonimo/i:

ASP2, BACE1, Beta Secretase, beta-Site APP Cleaving Enzyme

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About This Item

Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Origine biologica

rabbit

Livello qualitativo

Forma dell’anticorpo

purified immunoglobulin

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Reattività contro le specie

human, mouse

Produttore/marchio commerciale

Chemicon®

tecniche

western blot: suitable

N° accesso UniProt

Condizioni di spedizione

wet ice

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... BACE1(23621)

Specificità

Reacts with human BACE by Western blot.

Immunogeno

Synthetic peptide corresponding to amino acids 458 to 501 of human BACE (Vassar et al. 1999).

Applicazioni

Anti-BACE Antibody is an antibody against BACE for use in WB.
Research Category
Neuroscience
Research Sub Category
Neurodegenerative Diseases
Western blotting: 0.5-1.0 μg/mL on human brain tissue. The antibody recognizes a protein of molecular weight of 70 kDa in normal human brain lysate.

Optimal working dilutions must be determined by the end user.

Stato fisico

Format: Purified
Purified immunoglobulin. Liquid. Buffer = PBS containing 0.02% sodium azide.

Stoccaggio e stabilità

Maintain at 2-8°C in undiluted aliquots for up to 6 months.

Altre note

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Note legali

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Neuronal ?-amyloid generation is independent of lipid raft association of ?-secretase BACE1: analysis with a palmitoylation-deficient mutant.
Motoki, K; Kume, H; Oda, A; Tamaoka, A; Hosaka, A; Kametani, F; Araki, W
Brain and Behavior null
Naomi Mamada et al.
Molecular brain, 8(1), 73-73 (2015-11-11)
β-Site amyloid precursor protein cleaving enzyme 1 (BACE1) is a membrane-bound aspartyl protease that initiates amyloid β-protein (Aβ) generation. Aberrant elevation of BACE1 levels in brains of Alzheimer's disease (AD) patients may involve Aβ. In the present study, we used
Daisuke Tanokashira et al.
eNeuro, 2(2) (2015-10-16)
The β-secretase called BACE1 is a membrane-associated protease that initiates the generation of amyloid β-protein (Aβ), a key event in Alzheimer's disease (AD). However, the mechanism of intraneuronal regulation of BACE1 is poorly understood. Here, we present evidence that low-density
R Yan et al.
Nature, 402(6761), 533-537 (1999-12-11)
Mutations in the gene encoding the amyloid protein precursor (APP) cause autosomal dominant Alzheimer's disease. Cleavage of APP by unidentified proteases, referred to as beta- and gamma-secretases, generates the amyloid beta-peptide, the main component of the amyloid plaques found in
Expression of reticulon 3 in Alzheimer's disease brain.
H Kume,Y Konishi,K S Murayama,F Kametani,W Araki
Neuropathology and Applied Neurobiology null

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