AB3239-I

Anti-Myostatin Antibody, Near CT

from rabbit, purified by affinity chromatography

• Sinonimo/i: GDF8, Growth/differentiation factor 8, GDF-8, Myostatin
• Codice UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Livello qualitativo: 100
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Purificato mediante: affinity chromatography
• Reattività contro le specie: human
• Reattività contro le specie (prevista in base all’omologia): primate (based on 100% sequence homology), rat (based on 100% sequence homology), mouse (based on 100% sequence homology), monkey (based on 100% sequence homology), chimpanzee (based on 100% sequence homology)
• tecniche: immunohistochemistry: suitable; western blot: suitable
• N° accesso NCBI: NP_005250
• N° accesso UniProt: O14793
• Condizioni di spedizione: wet ice
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... MSTN(2660)

Descrizione

Descrizione generale

Myostatin, also known as Growth/differentiation factor 8, is a negative regulator of skeletal muscle growth encoded by the MSTN (also known as MSLHP and GDF8) gene in human. Myostatin is a member of the bone morphogenetic protein (BMP) family within the TGF-ß superfamily. Growth and differentation factor-associated serum protein-1 & 2 (GASP-1/2) and follistatin-related gene (FLRG) protein are reported to interact with myostatin and negatively regulate its activity (PMID 24019467, 17878677). Mutation in MSTN gene is known to cause muscle hypertrophy (MSLHP), a condition characterized by increased muscle bulk and strength.

Immunogeno

Epitope: Near C-terminal

KLH-conjugated linear peptide corresponding to human Myostatin near the C-terminal.

Applicazioni

Anti-Myostatin Antibody, Near CT is an antibody against Myostatin, Near CT for use in Western Blotting and Immunohistochemistry.

Immunohistochemistry Analysis: A 1:50-1,000 dilution from a representative lot detected Myostatin in human cardiac myocytes tissue.

Research Category
Signaling

Research Sub Category
Signaling Neuroscience

Qualità

Evaluated by Western Blotting in human adult heart tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected Myostatin in 10 µg of human adult heart tissue lysate.

Descrizione del bersaglio

~31 kDa observed. 30–32 kDa band assumed to be a glycosylated dimer of the carboxy terminus portion of the full length translational product (Artaza, J.N., et al. (2007). J. of Endocrinology. 194:63-76). This antibody also detected the 32-kDa band corresponding to the processed dimer (Artaza, J.N., et al. (2007). J. of Endocrinology. 146(8):3547-3557).

Stato fisico

Affinity

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stoccaggio e stabilità

Stable for 1 year at 2-8°C from date of receipt.

Altre note

Concentration: Please refer to lot specific datasheet.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable