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Key Documents

AB2201

Sigma-Aldrich

Anti-mPER1 (residues 6-21) Antibody

serum, from rabbit

Sinonimo/i:

Circadian clock protein PERIOD 1, Circadian pacemaker protein Rigui, Period, drosophila, homolog of period 1, period (Drosophila) homolog 1, period homolog 1 (Drosophila)

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About This Item

Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Origine biologica

rabbit

Livello qualitativo

100

Forma dell’anticorpo

serum

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Reattività contro le specie

human, mouse, rat

tecniche

western blot: suitable

N° accesso Genebanck

BAA94086

N° accesso UniProt

O35973

Condizioni di spedizione

wet ice

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

mouse ... Per1(18626)

Descrizione generale

This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The specific function of this gene is not yet known. Alternative splicing has been observed in this gene; however, these variants have not been fully described.

Specificità

Cat. # AB2201 will recognize the N-terminus of mPER1.
May react with Drosophila, Arvicanthis niloticus and Mesocricetus auratus based on sequence homology. Reactivity with other species has not been tested.

Applicazioni

Detect mPER1 (residues 6-21) using this Anti-mPER1 (residues 6-21) Antibody validated for use in WB.
Immunohistichemistry:
Tested on whole brain (SCN; peak staining at CT/ZT12). Optimium working dilutions need to be determined by end used.

Qualità

Routinely tested by western blot on human brain lysate

Descrizione del bersaglio

136 kDa

Note legali

GenBank is a registered trademark of United States Department of Health and Human Services

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Certificati d'analisi (COA)

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Yasuhiro Umemura et al.
Proceedings of the National Academy of Sciences of the United States of America, 119(1) (2021-12-22)
In mammals, circadian clocks are strictly suppressed during early embryonic stages, as well as in pluripotent stem cells, by the lack of CLOCK/BMAL1-mediated circadian feedback loops. During ontogenesis, the innate circadian clocks emerge gradually at a late developmental stage, and
D Shuboni et al.
Neuroscience, 170(4), 1172-1178 (2010-08-14)
The daily light dark cycle is the most salient entraining factor for the circadian system. However, in modern society, darkness at night is vanishing as light pollution steadily increases. The impact of brighter nights on wild life ecology and human
G Leach et al.
Neuroscience, 234, 31-39 (2013-01-15)
Seasonal affective disorder (SAD) is a major depressive disorder that recurs in the fall and winter when day-length gets short. It is well accepted that day-length is encoded by the principal circadian clock located in the suprachiasmatic nucleus (SCN), but
Rapid resetting of the mammalian circadian clock.
Best, J D, et al.
The Journal of Neuroscience, 19, 828-835 (1999)
Tomoko Ikeno et al.
Journal of biological rhythms, 31(4), 352-364 (2016-04-15)
In mammals, the circadian system is composed of a principal circadian oscillator located in the suprachiasmatic nucleus (SCN) and a number of subordinate oscillators in extra-SCN brain regions and peripheral tissues/organs. However, how the time-keeping functions of this multiple oscillator
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