AB1889
Anti-C-C Chemokine Receptor 5 Antibody, NT
Chemicon®, from rabbit
Sinonimo/i:
CCR-5, CD195
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About This Item
Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.43
Prodotti consigliati
Origine biologica
rabbit
Livello qualitativo
Forma dell’anticorpo
purified immunoglobulin
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Reattività contro le specie
human
Produttore/marchio commerciale
Chemicon®
tecniche
western blot: suitable
N° accesso NCBI
N° accesso UniProt
Condizioni di spedizione
wet ice
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... CCR5(1234)
Descrizione generale
HIV and related viruses require coreceptors, in addition to CD4, to infect target cells. Some G-protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors (1,2). Among them, CCR5 is a principle coreceptor for macrophage- and dual-tropic HIV-1 strains fusion of entry of human white blood cells (3,4). The amino-terminal domain and the extracellular loops of CCR5 serve as HIV binding sites. CCR5 messenger RNA is expressed in lymphoid organs and monocytes.
Specificità
Specific for human C-C Chemokine Receptor 5 (CCR5) at the N-terminus.
Immunogeno
Epitope: N-terminus
Synthetic peptide from the N-terminal domain of human CCR5.
Applicazioni
Anti-C-C Chemokine Receptor 5 Antibody, N-terminus is an antibody against C-C Chemokine Receptor 5 for use in WB.
Research Category
Inflammation & Immunology
Inflammation & Immunology
Research Sub Category
Cytokines & Cytokine Receptors
Cytokines & Cytokine Receptors
Western blot: 1:1000 - 1:2000 (THP-1 whole cell lysate can be used as a positive control)
Optimal working dilutions must be determined by end user.
Optimal working dilutions must be determined by end user.
Stato fisico
Format: Purified
Purified immunoglobulin. 100 μg purified IgG in 100 μL of PBS containing 0.2% sodium azide.
Stoccaggio e stabilità
Store at 2-8°C for up to 12 months.
Altre note
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Note legali
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 2
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
T Dragic et al.
Nature, 381(6584), 667-673 (1996-06-20)
The beta-chemokines MIP-1alpha, MIP-1beta and RANTES inhibit infection of CD4+ T cells by primary, non-syncytium-inducing (NSI) HIV-1 strains at the virus entry stage, and also block env-mediated cell-cell membrane fusion. CD4+ T cells from some HIV-1-exposed uninfected individuals cannot fuse
H Deng et al.
Nature, 381(6584), 661-666 (1996-06-20)
Entry of HIV-1 into target cells requires cell-surface CD4 and additional host cell cofactors. A cofactor required for infection with virus adapted for growth in transformed T-cell lines was recently identified and named fusin. However, fusin does not promote entry
Chemokine receptors: keys to AIDS pathogenesis?
D R Littman
Cell, 93(5), 677-680 (1998-06-18)
How do viruses enter cells? The HIV coreceptors teach us a lesson of complexity.
D S Dimitrov
Cell, 91(6), 721-730 (1997-12-31)
Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..
Contatta l'Assistenza Tecnica.