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Key Documents

8.55010

Sigma-Aldrich

NovaSyn®TGT alcohol resin

Novabiochem®

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About This Item

Numero CAS:
478242-36-3
Codice UNSPSC:
13111023
NACRES:
NA.22

Livello qualitativo

200

Nome Commerciale

NovaSyn® TG
Novabiochem®

Forma fisica

beads

Impiego in reazioni chimiche

reaction type: Fmoc solid-phase peptide synthesis

Produttore/marchio commerciale

Novabiochem®

applicazioni

peptide synthesis

Gruppo funzionale

alcohol

Temperatura di conservazione

2-8°C

Categorie correlate

Descrizione generale

NovaSyn TGT alcohol resin is derived from TG amino resin by acylation with Bayer′s 4-carboxytrityl linker [1]. Before use the resin must be converted to the chloride form by heating with AcCl [2,3] or SOCl2 [4,5] in toluene. The unstable trityl chloride resin should then be used immediately. Attachment of α-amino acids is free from enantiomerization, making this support ideal for the immobilization of sensitive residues such as Cys and His. Iodine oxidation of peptides containing Cys(Trt) occurs with release of the peptide from the resin. This support is also ideally suited to the synthesis of prolyl peptides as the bulk of the trityl handle prohibits diketopiperazine formation [6].Cleavage of protected peptide acids from this matrix can be effected by treatment with AcOH/MeOH/DCM [1], 0.5% TFA or HFIP [7].

Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins

Literature references

[1] E. Bayer, et al. in ′Peptides, Chemistry, Structure & Biology, Proc. 13th American Peptide Symposium′, R. S. Hodges & J. A. Smith(Eds), ESCOM, Leiden, 1994, pp. 156.
[2] J. M. J. Frechet, et al. (1975) Tetrahedron Lett., 3055.
[3] T. M. Fyles, et al. (1976) Can. J. Chem., 54,935.
[4] A. v. Vliet, et al. in ′Innovation & Perspectives in Solid Phase Synthesis, 2nd International Symposium′, R. Epton (Eds), Intercept UKLtd., Andover, 1992, pp. 475.
[5] A. v. Vliet, et al. in ′Peptides 1992, Proc. 22nd European Peptide Symposium′, C. H. Schneider & A. N. Eberle (Eds), ESCOM, Leiden,1993, pp. 279.
[6] G. Grübler, et al. in ′Innovation & Perspectives in Solid Phase Synthesis, 3rd International Symposium′, R. Epton (Eds), Mayflower Worldwide Ltd., Birmingham, 1994, pp. 517.
[7] R. Bollhagen, et al. (1994) J. Chem. Soc., Chem. Commun., 2559.

Linkage

Replaces: 01-64-0066

Risultati analitici

Color (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (determined from the substitution of the Fmoc-Leu loaded resin): 0.15 - 0.30 mmol/g
Swelling Volume (in CH₂Cl₂): lot specific result
The polymer matrix is NovaSyn TG resin (90 µm).

Note legali

NOVASYN is a registered trademark of Merck KGaA, Darmstadt, Germany
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Articoli

Linkers for Fmoc SPPS

Novabiochem® has one of the most extensive ranges of linkers and derivatized resins for Fmoc solid phase peptide synthesis. These resins have varied properties with special protocols for loading and cleaving.

Protocolli

Protocols for the Fmoc SPPS of Cysteine-containing Peptides

Overcome challenges in synthesis and disulfide bond formation with protocols for Fmoc solid-phase peptide synthesis of peptides with cysteine and methionine.

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