681525

Wiskostatin

A cell-permeable N-alkylated carbazole derivative that selectively blocks actin filament assembly.

• Sinonimo/i: Wiskostatin
• Formula empirica (notazione di Hill): C₁₇H₁₈Br₂N₂O
• Numero CAS: 253449-04-6
• Peso molecolare: 426.15
• Numero MDL: MFCD00218393
• Codice UNSPSC: 12352200

Proprietà

• Livello qualitativo: 100
• Saggio: ≥95% (HPLC)
• Forma fisica: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; protect from light
• Colore: white
• Solubilità: DMSO: 5 mg/mL
• Condizioni di spedizione: ambient
• Temperatura di conservazione: −20°C
• InChI: 1S/C17H18Br2N2O/c1-20(2)9-13(22)10-21-16-5-3-11(18)7-14(16)15-8-12(19)4-6-17(15)21/h3-8,13,22H,9-10H2,1-2H3; XUBJEDZHBUPBKL-UHFFFAOYSA-N

Descrizione

Descrizione generale

A cell-permeable N-alkylated carbazole derivative that selectively blocks actin filament assembly. Acts as a selective, reversible inhibitor of N-WASP (neural Wiskott Aldrich syndrome protein), a signal integrating protein. Appears to bind to N-WASP, stabilize the autoinhibited conformation and prevent the activation of Arp2/3 (actin-related protein 2/3) complex.

A cell-permeable N-alkylated carbazole derivative that selectively blocks actin filament assembly. Acts as a selective, reversible inhibitor of neural Wiskott Aldrich Syndrome protein (N-WASP). Reported to bind to N-WASP, stabilize the auto-inhibited conformation, and prevent the activation of actin-related protein 2/3 (Arp2/3) complex.

Azioni biochim/fisiol

Cell permeable: yes

Primary Target
N-WASP (neural Wiskott Aldrich syndrome protein)

Product does not compete with ATP.

Reversible: yes

Confezionamento

Packaged under inert gas

Attenzione

Toxicity: Standard Handling (A)

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Altre note

Peterson, J.R., et al. 2004. Nat. Struct. Mol. Biol.11, 747.
Peterson, J.R., and Mitchison, T.J. 2002. Chem. Biol.9, 1275.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Pittogrammi: GHS06
• Avvertenze: Danger
• Indicazioni di pericolo: H301 - H413
• Consigli di prudenza: P264 - P270 - P273 - P301 + P310 - P405 - P501
• Classi di pericolo: Acute Tox. 3 Oral - Aquatic Chronic 4
• Codice della classe di stoccaggio: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3