5.30959

TAZ Activity Modulator, TM-25659

• Sinonimo/i: TAZ Activity Modulator, TM-25659, TM25659, TM 25659
• Formula empirica (notazione di Hill): C₃₀H₂₈N₈
• Numero CAS: 260553-97-7
• Peso molecolare: 500.60
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Saggio: ≥97% (HPLC)
• Livello qualitativo: 100
• Forma fisica: powder
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; protect from light
• Colore: yellow
• Solubilità: DMSO: 50 mg/mL
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: CC1=NC2=C(N=C(CCCC)N2CC3=CC=C(C4=CC=CC=C4C5=NN=NN5)C=C3)C=C1C6=CN=CC=C6

Descrizione

Descrizione generale

A cell permeable, orally bioavailable imidazol-[4,5-b]pyridine derivative that enhances nuclear localization of transcriptional co-activator with PDZ-binding motif (TAZ) in a dose-dependent manner without affecting the total amount of TAZ in pluripotent C3H10T1/2 cells. Does not affect Ser89 phosphorylation in TAZ, but reduces tyrosine phosphorylation. Reduces PPARg levels in differentiated adipocytes and acts as a suppressor of PPARg-dependent adipocyte differentiation. Also shown to enhance RUNX2-induced osteoblast differentiation of C3H10T1/2 cells and mineralization in a dose-dependent manner. Reduces weight gain in ob/ob mice (50 mg/kg, i.p.) and attenuates bone loss in ovariectomized mice. Displays desirable pharmacokinetic properties with t_1/2 = 9.85 h.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

A cell permeable, orally bioavailable imidazol-pyrimidine derivative that enhances nuclear localization of transcriptional co-activator with PDZ-binding motif (TAZ) in a dose-dependent manner without affecting the total amount of TAZ in pluripotent C3H10T1/2 cells. Does not affect Ser89 phosphorylation in TAZ, but reduces tyrosine phosphorylation. Reduces PPARg levels in differentiated adipocytes and acts as a suppressor of PPARg-dependent adipocyte differentiation. Also shown to enhance RUNX2-induced osteoblast differentiation of C3H10T1/2 cells and mineralization in a dose-dependent manner. Reduces weight gain in ob/ob mice (50 mg/kg, i.p.) and attenuates bone loss in ovariectomized mice. Displays desirable pharmacokinetic properties with t1/2 = 9.85 h.

A cell-permeable enhancer of nuclear localization of transcriptional co-activator with PDZ-binding motif (TAZ). Does not affect the total amount of TAZ in pluripotent C3H10T1/2 cells.

Azioni biochim/fisiol

Cell permeable: yes

Attenzione

Toxicity: Standard Handling (A)

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Altre note

Jang, E.J., et al. 2012. Br. J. Pharmacol.165, 1584.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable