506274

PACOCF₃

A novel Ca²⁺-independent and reversible inhibitor of phospholipase A₂ (PLA₂; IC₅₀ = 3.8 µM).

• Sinonimo/i: PACOCF₃, Palmitoyl Trifluoromethyl Ketone
• Formula empirica (notazione di Hill): C₁₇H₃₁F₃O
• Numero CAS: 141022-99-3
• Peso molecolare: 308.42
• Numero MDL: MFCD00797669
• Codice UNSPSC: 12352211
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥97% (TLC)
• Stato: liquid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −20°C
• Stringa SMILE: FC(F)(F)C(=O)CCCCCCCCCCCCCCC
• InChI: 1S/C17H31F3O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(21)17(18,19)20/h2-15H2,1H3; MAHYXYTYTLCTQD-UHFFFAOYSA-N

Descrizione

Descrizione generale

A novel Ca²⁺-independent and reversible inhibitor of phospholipase A₂ (PLA₂; IC₅₀ = 3.8 µM). May also inhibit Ca²⁺-dependent PLA₂ at much higher concentrations (IC₅₀ = 45 µM).

A novel Ca²⁺-independent phospholipase A₂ inhibitor (IC₅₀ = 3.8 µM). May also inhibit Ca²⁺-dependent phospholipase A₂ at higher concentrations (IC₅₀ = 45 µM)

Azioni biochim/fisiol

Cell permeable: no

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 3.8 µM and 45 µM against phospholipase A2 (PLA2) and Ca2+-dependent PLA2, respectively.

Attenzione

Toxicity: Standard Handling (A)

Ricostituzione

Following reconstitution in DMSO, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Product has a very low melting point. The product will change from a solid to a liquid if held in your hand or kept at room temperature or warmer for any period of time. It is best to keep the product cool while in use by placing it in the refrigerator or on ice during experimentation. Once diluted in buffer, do not store in aqueous solutions for >1 day.

Supplied as a solution in ethanol. To change the solvent, evaporate the ethanol with a stream of nitrogen and immediately reconstitute with the solvent of choice. Soluble in DMSO (30 mg/ml). Only minimally soluble in aqueous buffers; do not use basic buffers; unstable at basic pH.

Altre note

Conde-Frieboes, K., et al. 1996. J. Am. Chem. Soc. 118, 5519.
Lio, Y.C., et al. 1996. Biochim. Biophys. Acta 1302, 55.
Ackermann, E.J., et al. 1995. J. Biol. Chem.270, 445.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3