5.00554

MHY1485

≥97% (HPLC), solid, mTOR activator, Calbiochem^®

• Sinonimo/i: mTOR Activator, MHY1485, 4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine, Autophagy Inhibitor III
• Formula empirica (notazione di Hill): C₁₇H₂₁N₇O₄
• Numero CAS: 326914-06-1
• Peso molecolare: 387.39
• Numero MDL: MFCD06591335
• Codice UNSPSC: 12352200
• ID PubChem: 2026662
• NACRES: NA.77

Proprietà

• Nome del prodotto: mTOR Activator, MHY1485,
• Saggio: ≥97% (HPLC)
• Livello qualitativo: 100
• Stato: solid
• Potenza: ~2 μM IC₅₀
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; protect from light
• Colore: pale yellow
• Solubilità: DMSO: 12.5 mg/mL
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: C1CCN(CC1)S(=O)(=O)C2=CC=C(C=C2)NC(=O)C3=CC(=NN3)C4=CC=CC=C4O
• InChI: VHYUALWDIXAVIZ-UHFFFAOYSA-N

Descrizione

Descrizione generale

MHY1485, a small-molecule activator of the mammalian target of rapamycin (mTOR), exerts an inhibitory effect on the autophagic process by preventing the fusion between autophagosomes and lysosomes, resulting in the accumulation of LC3II protein and the enlargement of autophagosomes. It can also protect osteoblasts from dexamethasone-induced damage by inhibiting the mitochondrial death pathway provoked by dexamethasone.

Applicazioni

mTOR Activator, MHY1485 has been used to activate the mammalian target of rapamycin (mTOR) pathway in mice with Parkinson disease (PD) to reverse the effects of tumor necrosis factor α–induced protein 3 (TNFAIP3) on the mitigation of injury in mice and in SK-N-SH cells induced with 1-Methyl-4-phenylpyridinium (MPP+).

Azioni biochim/fisiol

Cell permeable: yes

Reversible: yes

Confezionamento

Packaged under inert gas

Attenzione

Toxicity: Standard Handling (A)

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Altre note

Choi, Y. J., et al. 2012. PLoS. One.7, e43418.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable