422686

Kininogen, High Molecular Weight, Single Chain, Human Plasma

Native, single chain, high molecular weight Kininogen from human plasma.

• Sinonimo/i: High molecular weight kininogen
• Codice UNSPSC: 12352202
• NACRES: NA.28

Proprietà

• Livello qualitativo: 100
• Saggio: ≥95% (SDS-PAGE)
• Forma fisica: liquid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; avoid repeated freeze/thaw cycles
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −70°C

Descrizione

Descrizione generale

Native, single chain, high molecular weight Kininogen from human plasma. Non-enzymatic cofactor of the contact activation system. Links prekallikrein to negatively charged surfaces, thereby allowing activation to kallikrein by surface-bound Factor a-XIIa. Also circulates in plasma in complex with Factor XI, that may play a role in the activation of Factor XI to Factor XIa by Factor α-XIIa. Serves as a source of bradykinin, a potent vasoactive peptide important in hypotension studies.

Native, single chain, high molecular weight Kininogen from human plasma. Nonenzymatic cofactor of the contact activation system. Links prekallikrein to negatively charged surfaces, thereby allowing activation to kallikrein by surface-bound Factor α-XIIa. Also circulates in plasma in complex with Factor XI and may play a role in the activation of Factor XI to Factor XIa by Factor α-XIIa. Serves as a source of bradykinin, a potent vasoactive peptide important in hypotension studies.

Confezionamento

Please refer to vial label for lot-specific concentration.

Attenzione

Toxicity: Standard Handling (A)

Stato fisico

In 150 mM NaCl, 4 mM sodium acetate buffer, pH 5.3.

Nota sulla preparazione

Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Ricostituzione

Following initial thaw, aliquot and freeze (-70°C).

Altre note

Weisel, J.W., et al. 1994. J. Biol. Chem. 269, 10100.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable