344847

Fumitremorgin C

from Aspergillus. fumigatus, ≥95% (HPLC), lyophilized, BCRP/ABCG2 inhibitor, Calbiochem^®

• Sinonimo/i: Fumitremorgin C, Aspergillus. fumigatus, NSC719655, FTC
• Formula empirica (notazione di Hill): C₂₂H₂₅N₃O₃
• Numero CAS: 118974-02-0
• Peso molecolare: 379.45
• Numero MDL: MFCD08702652
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• product name: Fumitremorgin C, Aspergillus. fumigatus, A cell-permeable indolyldiketopiperazinyl mycotoxin that inhibits BCRP/ABCG2 (breast cancer resistance protein/ATP-binding cassette G2) multidrug transport activity.
• Livello qualitativo: 100
• Saggio: ≥95% (HPLC)
• Forma fisica: lyophilized
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; protect from light
• Solubilità: DMSO: 10 mg/mL; ethanol: 5 mg/mL
• Condizioni di spedizione: ambient
• Temperatura di conservazione: 2-8°C
• InChI: 1S/C22H25N3O3/c1-12(2)9-18-20-15(14-7-6-13(28-3)10-16(14)23-20)11-19-21(26)24-8-4-5-17(24)22(27)25(18)19/h6-7,9-10,17-19,23H,4-5,8,11H2,1-3H3/t17-,18-,19-/m0/s1; DBEYVIGIPJSTOR-FHWLQOOXSA-N

Descrizione

Descrizione generale

A cell-permeable indolyldiketopiperazinyl mycotoxin that inhibits BCRP/ABCG2 (breast cancer resistance protein/ATP-binding cassette G2) multidrug transport activity. Also acts as a potent and specific chemosenzitizing agent.

A cell-permeable indolyldiketopiperazinyl mycotoxin that inhibits the ATPase and multidrug resistance activity of BCRP/ABCG2 (breast cancer resistance protein/ATP-binding cassette G2) without affecting the activity of MDR1. Also acts as a potent and specific chemosenzitizing agent. Suggested concentration for cell inhibition studies: ~1-5 µM.

Azioni biochim/fisiol

Cell permeable: yes

Primary Target
BCRP/ABCG2 (breast cancer resistance protein/ATP-binding cassette G2)

Product does not compete with ATP.

Reversible: no

Confezionamento

Packaged under inert gas

Attenzione

Toxicity: Toxic (F)

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Altre note

Allen, J.D., et al. 2002. Mol. Cancer Ther.1, 417.
Ozvegy, C., et al. 2001. Biochem. Biophys. Res. Commun.285, 111.
Rabindran, S.K., et al. 2000. Cancer Res.60, 47.
Rabindran, S.K., et al. 1998. Cancer Res.58, 5850.
Cole, R.J., et al. 1977. J. Agric. Food Chem.25, 826.

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable