344216

Formyl Peptide Receptor-Like 1 Agonist, WKYMVm

The Formyl Peptide Receptor-Like 1 Agonist, WKYMVm controls the biological activity of Formyl Peptide Receptor-Like 1. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

• Sinonimo/i: Formyl Peptide Receptor-Like 1 Agonist, WKYMVm, H₂N-WKYMV- D-M-CONH₂, FPRL1 Agonist, WKYMVm, H₂N-WKYMV-D-M-CONH₂, FPRL1 Agonist, WKYMVm
• Formula empirica (notazione di Hill): C₄₁H₆₁N₉O₇S₂
• Peso molecolare: 856.11
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥95% (HPLC)
• Forma fisica: lyophilized
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; desiccated (hygroscopic); protect from light
• Solubilità: DMSO: 10 mg/mL
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −20°C

Descrizione

Descrizione generale

A potent chemoattractant that enhances leukocyte activity via activation of Formyl Peptide Receptor-Like 1 (FPRL1). More poteut than fmlp at inducing neutrophil chemotaxis, neutrophil complement receptor 3. Shown to activate phospholipase C-mediated inositol phosphate formation in human U266 myeloma cells (EC₅₀ = 510 pM) and in U937 and HL60 cells. Has no effect inositide phosphate synthecs in a variety of other cell lines (e.g. NIH3T3, PC12, Daudi, Sp2, Jurkat, H9, Molt-4, SupT-1, K562, and RBL-2H3). Radioiodinatable at the tyrosine residue.

A potent chemoattractant that enhances leukocyte activity via activation of Formyl Peptide Receptor-Like 1 (FPRL1). Shown to activate phospholipase C-mediated inositol phosphate formation in human U266 myeloma cells (EC₅₀ = 510 pM). Also shown to stimulate inositol phosphate formation in U937 and HL60 cells, but has no effect on a variety of other cell lines (e.g. NIH3T3, PC12, Daudi, Sp2, Jurkat, H9, Molt-4, SupT-1, K562, and RBL-2H3). Stimulates phagocyte chemotaxis and [Ca²⁺] flux, and is more effective than fMLP (Cat. No. 05-22-2500) in generating superoxide in human neutrophils. Radioiodinatable at the tyrosine residue.

Azioni biochim/fisiol

Cell permeable: no

EC50 = 510 pM in activating phospholipase C-mediated inositol phosphate formation in human U266 myeloma cells

Primary Target
Formyl Peptide Receptor-Like 1

Product does not compete with ATP.

Reversible: no

Confezionamento

Packaged under inert gas

Attenzione

Toxicity: Standard Handling (A)

Sequenza

H-Trp-Lys-Tyr-Met-Val-D-Met-CONH₂

Stato fisico

Supplied as a trifluoroacetate salt.

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Altre note

Bae, Y.S., et al. 2004. J. Immunol.173, 607.
Bae, Y.S., et al. 2003. Mol. Pharmacol.64, 841.
Le, Y., et al. 1999. J. Immunol.163, 6777.
Seo, J.K., et al. 1997. J. Immunol.158, 1895.
Baek, S.H., et al. 1996. J. Biol. Chem.271, 8170.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable