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Key Documents

14-439-M

Sigma-Aldrich

MAP Kinase 1/Erk1 Protein, active, 10 µg

Active, recombinant, full-length, human MAP Kinase 1/Erk1 containing an N-terminal GST tag, for use in Kinase Assays.

Sinonimo/i:

ERT1, Extracellular signal-regulated kinase 2 (ERK-2), MAPK 1, Mitogen-activated protein kinase 1, p44 MAPK

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About This Item

Codice UNSPSC:
12352200
eCl@ss:
32160405
NACRES:
NA.32

Origine biologica

human

Livello qualitativo

100

Ricombinante

expressed in E. coli

Forma fisica

liquid

PM

Mw 69.9 kDa

Produttore/marchio commerciale

Upstate®

tecniche

activity assay: suitable (kinase)

Colore

colorless

Solubilità

water: soluble

N° accesso NCBI

NM_002745.4
NM_138957.3

N° accesso UniProt

P28482

Informazioni sul gene

human ... MAPK3(5595)

Descrizione generale

Research area: Cell Signaling

Recombinant, full-length, human MAP Kinase 1/Erk1 containing an N-terminal GST tag

Azioni biochim/fisiol

Extracellular-signal-regulated kinase 1 (ERK1)/ Extracellular-signal-regulated kinase 2 (ERK2), as part of the Ras-Raf-MEK-ERK signal transduction cascade, are involved in regulating a wide range of cellular processes, including cell adhesion, cell cycle progression, cell migration, cell survival, differentiation, metabolism, proliferation, and transcriptional control. Additionally, ERK1 signaling contributes to the regulation of cyclin D1 expression during the cell cycle. MAP kinases play a crucial role in inflammation and immune responses by regulating the production of pro- and anti-inflammatory cytokines, as well as prostaglandins, in response to lipopolysaccharide (LPS) stimulation.

Confezionamento

Also available in 250μg size as catalog # 14-439M - Call for pricing and availability.

Qualità

routinely evaluated by phosphorylation of MBP

Stato fisico

Purified by glutathione-agarose. Activated with MEK1 and repurified on Ni2+/NTA agarose

Altre note

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Note legali

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Y Zhang et al.
The Journal of biological chemistry, 276(24), 20913-20923 (2001-03-30)
Ultraviolet light A (UVA) plays an important role in the etiology of human skin cancer, and UVA-induced signal transduction has a critical role in UVA-induced skin carcinogenesis. The upstream signaling pathways leading to p70(S6K) phosphorylation and activation are not well
Lucinda F Reynolds et al.
The Journal of biological chemistry, 279(18), 18239-18246 (2004-02-07)
Vav1 is a signaling protein required for both positive and negative selection of CD4(+)CD8(+) double positive thymocytes. Activation of the ERK MAPK pathway is also required for positive selection. Previous work has shown that Vav1 transduces T cell receptor (TCR)

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