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Key Documents

CdA/CdQ

12-555

Crosstide KK

Name: Crosstide KK
Brand: MM

Crosstide KK primarily used in Kinase Assays.

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About This Item

Codice UNSPSC:

12352202

eCl@ss:

32160405

NACRES:

NA.42

Livello qualitativo

100

Produttore/marchio commerciale

Upstate^®

tecniche

activity assay: suitable (kinase)

N° accesso NCBI

NM_001033578.1
NM_013257.3
NM_170709.1

N° accesso UniProt

Q96BR1

Condizioni di spedizione

wet ice

Informazioni sul gene

human ... SGK3(23678)

Azioni biochim/fisiol

Protein Target: SGK3

Target Sub-Family: AGC

Qualità

Routinely evaluated by phosphorylation using SGK3, active (Catalog # 14-647).

Stoccaggio e stabilità

2 years at 4°C

Note legali

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Certificati d'analisi (COA)

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GLUT4 translocation precedes the stimulation of glucose uptake by insulin in muscle cells: potential activation of GLUT4 via p38 mitogen-activated protein kinase.

R Somwar et al.

The Biochemical journal, 359(Pt 3), 639-649 (2001-10-24)

We previously reported that SB203580, an inhibitor of p38 mitogen-activated protein kinase (p38 MAPK), attenuates insulin-stimulated glucose uptake without altering GLUT4 translocation. These results suggested that insulin might activate GLUT4 via a p38 MAPK-dependent pathway. Here we explore this hypothesis

The antihyperglycemic drug alpha-lipoic acid stimulates glucose uptake via both GLUT4 translocation and GLUT4 activation: potential role of p38 mitogen-activated protein kinase in GLUT4 activation.

D Konrad et al.

Diabetes, 50(6), 1464-1471 (2001-05-26)

The cofactor of mitochondrial dehydrogenase complexes and potent antioxidant alpha-lipoic acid has been shown to lower blood glucose in diabetic animals. alpha-Lipoic acid enhances glucose uptake and GLUT1 and GLUT4 translocation in 3T3-L1 adipocytes and L6 myotubes, mimicking insulin action.

Mechanism of activation of protein kinase B by insulin and IGF-1.

D R Alessi et al.

The EMBO journal, 15(23), 6541-6551 (1996-12-02)

Insulin activated endogenous protein kinase B alpha (also known as RAC/Akt kinase) activity 12-fold in L6 myotubes, while after transfection into 293 cells PKBalpha was activated 20- and 50-fold in response to insulin and IGF-1 respectively. In both cells, the

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