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Merck
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Key Documents

07-633

Sigma-Aldrich

Anti-HNF3β/FOXA2 Antibody

Upstate®, from rabbit

Sinonimo/i:

Anti-HNF-3-beta, Anti-HNF3B, Anti-TCF3B

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About This Item

Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Origine biologica

rabbit

Forma dell’anticorpo

purified immunoglobulin

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Reattività contro le specie

mouse, human, rat

Produttore/marchio commerciale

Upstate®

tecniche

immunohistochemistry: suitable
western blot: suitable

Isotipo

IgG

N° accesso UniProt

Condizioni di spedizione

wet ice

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... FOXA2(3170)
mouse ... Foxa2(15376)
rat ... Foxa2(25099)

Descrizione generale

This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporatic cases of maturity-onset diabetes of the young. Two transcript variants encoding the same protein have been identified for this gene.

Specificità

Recognizes HNF3β/FOXA2.

Immunogeno

GST fusion protein corresponding to residues 7-86 of rat hepatocyte nuclear factor-3 beta / forkhead box A2 (HNF3β/FOXA2)

Applicazioni

Detect HNF3β/FOXA2 with Anti-HNF3β/FOXA2 Antibody (Rabbit Polyclonal Antibody), that has been shown to work in IHC & WB.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors

Qualità

Routinely evaluated by immunoblot with nuclear extracts from MLE 12 cells

Descrizione del bersaglio

50 kDa

Stato fisico

Format: Purified
Protein A Purified rabbit IgG in a solution of 30% glycerol, 0.07M Tris-glycine, pH 7.4, 0.135M NaCl, and 0.035% sodium azide as a preservative.
Protein A purified

Stoccaggio e stabilità

Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Risultati analitici

Control
MLE 12 nuclear extracts, human liver lysate

Altre note

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Note legali

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1


Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Temporal-spatial distribution of hepatocyte nuclear factor-3beta in developing human lung and other foregut derivatives.
Stahlman, M T, et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 46, 955-962 (1998)
Fgf10 gene expression is delayed in the embryonic lung mesenchyme in the adriamycin mouse model.
Piotr Hajduk,Paula Murphy,Prem Puri
Pediatric Surgery International null
Claudia Davenport et al.
Stem cells (Dayton, Ohio), 34(11), 2635-2647 (2016-06-15)
As known from model organisms, such as frog, fish, mouse, and chicken, the anterior-posterior patterning of the definitive endoderm (DE) into distinct domains is controlled by a variety of signaling interactions between the DE and its surrounding mesoderm. This includes
Forkhead box A2 transcription factor is expressed in all types of neuroendocrine lung tumors
Khoor, Andras, et al.
Human Pathology, 35, 560-564 (2004)
Mesenchymal expression of Tbx4 gene is not altered in Adriamycin mouse model.
Piotr Hajduk,Paula Murphy,Prem Puri
Pediatric Surgery International null

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