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Merck
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Key Documents

07-618

Sigma-Aldrich

Anti-SF-1 Antibody

Upstate®, from rabbit

Sinonimo/i:

Anti-AD4BP, Anti-FTZ1, Anti-FTZF1, Anti-POF7, Anti-SF-1, Anti-SF1, Anti-SPGF8, Anti-SRXX4, Anti-SRXY3, Anti-hSF-1

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About This Item

Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Origine biologica

rabbit

Livello qualitativo

Forma dell’anticorpo

purified immunoglobulin

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Reattività contro le specie

mouse

Produttore/marchio commerciale

Upstate®

tecniche

western blot: suitable

Isotipo

IgG

N° accesso NCBI

N° accesso UniProt

Condizioni di spedizione

dry ice

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

Descrizione generale

Steroidogenic factor-1 (SF-1) regulates multiple genes involved in the adrenal and gonadal development and in the biosynthesis of a variety of hormones, including adrenal and gonadal steroids, anti-Mullerian hormone (AMH), and gonadotropins. SF-1 belongs to the fushi tarazu factor-1 (FTZ-F1) subfamily of orphan nuclear receptors. In the adult ovary, SF-1 localizes to theca/interstitial cells.

Specificità

Recognizes SF-1.

Immunogeno

DNA binding domain of SF-1 from mouse, produced in E. coli as a GST fusion protein and partially purified via GST-agarose column chromatography

Applicazioni

Anti-SF-1 Antibody is a high quality Rabbit Polyclonal Antibody for the detection of SF-1 & has been validated in WB.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors

Qualità

Routinely evaluated by immunoblot on RIPA lysates from Y1 cells

Descrizione del bersaglio

53 kDa

Stato fisico

Format: Purified
Protein A Purified immunoglobulin in 30% glycerol, 0.07M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide as a preservative.
Protein A purified

Stoccaggio e stabilità

Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Risultati analitici

Control
Y1 cell lysate

Altre note

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Note legali

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2


Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Hormonal regulation of microRNA expression in steroid producing cells of the ovary, testis and adrenal gland.
Hu, Z; Shen, WJ; Cortez, Y; Tang, X; Liu, LF; Kraemer, FB; Azhar, S
Testing null
Steroidogenic factor 1: an essential mediator of endocrine development
Parker, Keith L, et al
Recent Progress in Hormone Research, 57, 19-36 (2002)
Steroidogenic factor-1: a key regulator of gonadotroph gene expression
Fowkes, R C and Burrin, J M
The Journal of Endocrinology, 177, 345-350 (2003)
Steroidogenic factor-1 is an essential transcriptional activator for gonad-specific expression of promoter I of the rat prolactin receptor gene
Hu, Z, et al
The Journal of Biological Chemistry, 272, 14263-14271 (1997)
Bruno Ferraz-de-Souza et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 25(4), 1166-1175 (2010-12-18)
The nuclear receptor steroidogenic factor-1 (SF-1, NR5A1) is a key regulator of adrenal and gonadal biology. Disruption of SF-1 can lead to disorders of adrenal development, while increased SF-1 dosage has been associated with adrenocortical tumorigenesis. We aimed to identify

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