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Key Documents

07-228

Sigma-Aldrich

Anti-TACC2 Antibody

Upstate®, from rabbit

Sinonimo/i:

transforming, acidic coiled-coil containing protein 2

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About This Item

Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Origine biologica

rabbit

Livello qualitativo

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Purificato mediante

affinity chromatography

Reattività contro le specie

human, mouse

Reattività contro le specie (prevista in base all’omologia)

rat (based on 100% sequence homology)

Produttore/marchio commerciale

Upstate®

tecniche

western blot: suitable

N° accesso NCBI

N° accesso UniProt

Condizioni di spedizione

wet ice

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... TACC2(10579)

Descrizione generale

TACC2, also known as transforming acidic coiled-coil-containing protein 2, belongs to the transforming acidic coiled-coil-containing (TACC) protein family. This group of proteins is defined by its highly conserved coiled-coil domain. This domain is necessary for the assignment of the centrosome-spindle apparatus during cell cycling. There are three proteins belonging to the TACC family; TACC1, TACC2, and TACC3. TACC2 has been reported as playing a necessary role in cultured cell microtubule stabilization. It has also been shown that the binding of TACC2 by T antigen can cause chromosomal instability and mitotic defects (Tei, 2009). Research into the over expression of TACC2 strongly suggests a potential function as a tumor suppressor (Tei, 2009).

Immunogeno

KLH-conjugated linear peptide corresponding to the mature chain of mouse TACC2.

Applicazioni

Anti-TACC2 Antibody is a Rabbit Polyclonal Antibody for detection of TACC2 also known as transforming acidic coiled-coil containing protein 2 & has been validated in WB.

Qualità

Evaluated by Western Blot in mouse testis tissue lysate.

Western Blot Analysis: 2 µg/mL of this antibody detected TACC2 on 10 µg of mouse testis tissue lysate.

Descrizione del bersaglio

Observed molecular weight, 73 kDa
Note this protein can be highly modified and several isoforms exist.

Altre note

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Note legali

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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T L Wong et al.
Journal of applied microbiology, 103(4), 803-810 (2007-09-28)
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T L Buhr et al.
Journal of applied microbiology, 115(2), 398-408 (2013-05-23)
To develop test methods and evaluate survival of Bacillus anthracis Ames, B. anthracis ∆Sterne and B. thuringiensis Al Hakam spores after exposure to PES-Solid (a solid source of peracetic acid), including PES-Solid formulations with bacteriostatic surfactants. Spores (≥ 7 logs)
TACC1-chTOG-Aurora A protein complex in breast cancer.
Conte, N; Delaval, B; Ginestier, C; Ferrand, A; Isnardon, D; Larroque, C; Prigent et al.
Oncogene null
Ken-ichi Takayama et al.
Molecular endocrinology (Baltimore, Md.), 26(5), 748-761 (2012-03-30)
Despite the existence of effective antiandrogen therapy for prostate cancer, the disease often progresses to castration-resistant states. Elucidation of the molecular mechanisms underlying the resistance for androgen deprivation in terms of the androgen receptor (AR)-regulated pathways is a requisite to
Molecular cloning, genomic structure and interactions of the putative breast tumor suppressor TACC2.
Brenda Lauffart, Omkaram Gangisetty, Ivan H Still
Genomics null

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