06-138
Anti-Cyclin A Antibody
Upstate®, from rabbit
Sinonimo/i:
Anti-CCN1, Anti-CCNA
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About This Item
Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Prodotti consigliati
Origine biologica
rabbit
Livello qualitativo
Forma dell’anticorpo
purified immunoglobulin
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Reattività contro le specie
rat, sheep, human, mouse
Produttore/marchio commerciale
Upstate®
tecniche
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
Isotipo
IgG
N° accesso NCBI
N° accesso UniProt
Condizioni di spedizione
dry ice
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... CCNA2(890)
Descrizione generale
The cell cycle is regulated by the interplay of many molecules. Key among these are the cyclins which are expressed and then degraded in a concerted fashion to drive the stages of the cell cycle. Cyclins combine with cyclin dependent kinases (cdks) to form activated kinases that phosphorylate targets leading to cell cycle regulation. A breakdown in the regulation of this cycle can lead to out of control growth and contribute to tumor formation. Defects in many of the molecules that regulate the cell cycle have been implicated in cancer. Cyclin A is a member of the Cyclin A family that can bind and activate Cdc2 and Cdk2 and is involved in the control of mitosis and S phase. During S phase, cyclin A forms a complex with Cdk2, the pRB-related protein p107 and E2F.
Specificità
p58cyclin A; does not cross-react with cyclin B or cyclin D2, or 3
Immunogeno
peptide corresponding amino acid residues 417-432 (C-KHGVSLLNPPETL-N-L)
Applicazioni
Detect Cyclin A with Anti-Cyclin A Antibody (Rabbit Polyclonal Antibody), that has been shown to work in IP, WB, ICC.
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Cell Cycle, DNA Replication & Repair
Cell Cycle, DNA Replication & Repair
Qualità
routinely evaluated by immunoblot on HeLa nuclear extract
Descrizione del bersaglio
58kDa
Stato fisico
Format: Purified
Lyophilized
Protein G Chromatography
Stoccaggio e stabilità
2 years at -20°C
Risultati analitici
Control
Positive Antigen Control: Catalog #12-309, Hela cell nuclear extract. Add an equal volume of Laemmli reducing sample buffer to 10 μL of extract and boil for 5 minutes to reduce the preparation. Load 20 μg of reduced extract per lane for minigels.
Positive Antigen Control: Catalog #12-309, Hela cell nuclear extract. Add an equal volume of Laemmli reducing sample buffer to 10 μL of extract and boil for 5 minutes to reduce the preparation. Load 20 μg of reduced extract per lane for minigels.
Note legali
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Warning
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Certificati d'analisi (COA)
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Sole BCR-ABL inhibition is insufficient to eliminate all myeloproliferative disorder cell populations.
Wong, S; McLaughlin, J; Cheng, D; Zhang, C; Shokat, KM; Witte, ON
Proceedings of the National Academy of Sciences of the USA null
Culture in low levels of oxygen enhances in vitro proliferation potential of satellite cells from old skeletal muscles.
M V Chakravarthy, E E Spangenburg, F W Booth
Cellular and Molecular Life Sciences null
Characterization of the cytoplasmic proline-directed protein kinase in proliferative cells and tissues as a heterodimer comprised of p34cdc2 and p58cyclin A.
Hall, F L, et al.
The Journal of Biological Chemistry, 266, 17430-17440 (1991)
J M Trowbridge et al.
Proceedings of the National Academy of Sciences of the United States of America, 94(19), 10132-10137 (1997-09-18)
We have found that ectopic expression of cyclin A increases hormone-dependent and hormone-independent transcriptional activation by the estrogen receptor in vivo in a number of cell lines, including HeLa cells, U-2 OS osteosarcoma cells and Hs 578Bst breast epithelial cells.
TopBP1 mediates mutant p53 gain of function through NF-Y and p63/p73.
Liu, K; Ling, S; Lin, WC
Molecular and cellular biology null
Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..
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